Studies on DNA-binding and plasmid-cleavage of cobalt (III) mixed ligand complexes

被引：2

作者：

Shilpa, Mynam ^{[1
]}

Nagababu, Penumaka ^{[1
]}

Satyanarayana, S. ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

MAIN GROUP CHEMISTRY | 2009年 / 8卷 / 01期

关键词：

cobalt (III); complexes; DNA-binding; plasmid-cleavage; DIPYRIDOPHENAZINE COMPLEXES; ETHYLENEDIAMINE COBALT(III); POLYPYRIDYL COMPLEXES; PHOTOCLEAVAGE; TRIS(PHENANTHROLINE)RUTHENIUM(II); RECOGNITION; RUTHENIUM; DRUGS; ION;

D O I：

10.1080/10241220902962929

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mixed ligand cobalt (III) complexes of [Co(phen)(2)nip](3+), [Co(phen)(2)apip](3+), [Co(bpy)(2)nip](3+), [Co(bpy)(2)apip](3+) where [apip = 2(4-aminophenyl)imidazo[4,5f][1,10] [phenanthroline], [nip = 2(2-napthyl)14-midazo[4,5-f][1,10]phenanthroline] have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption (UV/Vis), emission spectroscopy, viscosity measurements, and DNA melting. The results suggest that the complexes bind to DNA via the intercalative mode with complexes 1 > 2 > 3 > 4 binding more strongly to CT DNA. Moreover, these complexes have been found to promote the photocleavage of plasmid DNA pBR322.

引用

页码：33 / 45

页数：13

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