Spreading depression and peri-infarct depolarizations.: Their potential roles in migraine and stroke

被引：0
|
作者：
Röther, J [1 ]
机构：
[1] Univ Hamburg, Krankenhaus Eppendorf, Neurol Klin, D-20246 Hamburg, Germany
来源：
NERVENARZT | 2000年 / 71卷 / 02期
关键词：
spreading depression; peri-infarct depolarization; migraine; stroke;
D O I：
10.1007/s001150050012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Spreading depression is a fascinating phenomenon that can be provoked by chemical, electrical or mechanical stimuli of the cortex. Spreading depression-like transient depolarizations are observed in the periinfarct tissue after focal ischemia. The reduction in electrical activity and a negative direct current potential shift propagating over the cortex with a rate of 2-5 mm/minute are the physiological hallmarks. It is thought that spreading depression and peri-infarct depolarizations might play a role in the pathogenesis of migraine and stroke. However, these events have never been detected in humans. This paper reviews the physiological characteristics of spreading depression and peri-infarct depolarizations and discusses their potential role in migraine and stroke.
引用
收藏
页码：84 / 90
页数：7
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