Re-examining class-I presentation and the DRiP hypothesis

被引：72
|
作者：
Rock, Kenneth L. [1 ]
Farfan-Arribas, Diego J. [1 ]
Colbert, Jeff D. [1 ]
Goldberg, Alfred L. [2 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01605 USA
[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
来源：
TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 04期
基金：
美国国家卫生研究院;
关键词：
MHC CLASS-I; NEWLY SYNTHESIZED PROTEINS; DEFECTIVE RIBOSOMAL PRODUCTS; T-CELL RESPONSE; ANTIGEN PRESENTATION; QUALITY-CONTROL; COTRANSLATIONAL UBIQUITINATION; PROTEASOME INHIBITORS; ENDOPLASMIC-RETICULUM; PRESENTATION PATHWAY;
D O I：
10.1016/j.it.2014.01.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
MHC class I molecules present peptides derived from intracellular proteins, enabling immune surveillance by CD8(+) T cells and the elimination of virus-infected and cancerous cells. It has been argued that the dominant source of MHC class l-presented peptides is through proteasomal degradation of newly synthesized defective proteins, termed defective ribosomal products (DRiPs). Here, we critically examine the DRiP hypothesis and discuss recent studies indicating that antigenic peptides are generated from the entire proteome and not just from failures in protein synthesis or folding.
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页码：144 / 152
页数：9
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