Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients

被引：55

作者：

Perinel, Sophie ^{[1
,2
]}

Launay, Manon ^{[3
]}

Botelho-Nevers, Elisabeth ^{[4
]}

Diconne, Eric ^{[1
]}

Louf-Durier, Aurore ^{[1
]}

Lachand, Raphael ^{[1
]}

Murgier, Martin ^{[1
]}

Page, Dominique ^{[1
]}

Vermesch, Regine ^{[1
]}

Thierry, Guillaume ^{[1
]}

Delavenne, Xavier ^{[2
,3
]}

机构：

[1] Ctr Hosp Univ CHU St Etienne, Serv Med Intens & Reanimat, St Etienne, France

[2] Univ Lyon, Inst Natl Sante & Rech Med U1059, Dysfonct Vasculaires & Hemostase, St Etienne, France

[3] CHU St Etienne, Lab Pharmacol Toxicol Gaz Sang, St Etienne, France

[4] CHU St Etienne, Infect Dis Dept, St Etienne, France

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 71卷 / 16期

关键词：

hydroxychloroquine; pharmacokinetic; COVID-19; SARS-Cov2; intensive care; PHARMACOKINETICS; TABLETS;

D O I：

10.1093/cid/ciaa394

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hydroxychloroquine (HCQ) appears to be a promising treatment for COVID-19. However, all ongoing clinical trials with HCQ use different dosing regimens, resulting in various concentrations. Pharmacokinetic studies are therefore needed to define the optimal dosing regimen.

引用

页码：2227 / 2229

页数：3

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