Postictal psychosis syndrome: A clinical entity to be recognized

Introduction. - Post-ictal psychosis syndrome (PIP) belongs to the group of epileptic psychoses which, according to the most commonly used classification, is to be distinguished from ictal psychoses, on one hand, and from inter-ictal psychoses, on the other. Objectives. - The present paper aims to review recent data concerning the clinical, therapeutic and pathophysiological aspects of PIP. Methods. - We report four cases of PPI, which involved four patients hospitalized at the Salpetriere hospital between 2001 and 2005, and discuss these cases in light of the relevant literature. Results. - The PIP fit generally occurs in patients suffering from intractable temporal lobe epilepsy which started several years before. The psychiatric disorders suddenly take hold after a series of complex partial seizures with frequent secondarily generalized tonic clonic seizures. During the episode, EEG recordings do not show any epileptic activity. Psychiatric symptoms consist of persecutory delusive ideas, verbal and visual hallucinations, agitation, and aggressiveness. Mood disorders are variable from one patient to another and exhibit intraindividual fluctuation. in most patients given antipsychotic drugs, the short-term outcome of PIP is favorable. In the long-term, even if recurrence is the main long-term risk, progression to severe mood disorders or to poor prognosis inter-ictal psychosis is possible. Accordingly, the clinician must be aware of this syndrome in order to correctly diagnose PIP since effective treatment with antipsychotic drugs is available. Conclusion. - The short-term prognosis of PPI is usually favorable but this syndrome can potentially develop in the long-term to more severe psychiatric disorders. it is, therefore, important to recognize PIP syndromes which respond more readily to pharmacological treatments than other types of psychoses. (C) 2008 Elsevier Masson SAS. Tous droits reserves.