Improved non-viral CAR-reprogramming of human T cells using CRISPR-Cas and double-stranded DNA

被引:0
|
作者
Kath, J. [1 ,2 ,3 ]
Du, W. [1 ,2 ,3 ]
Glaser, V. [1 ,2 ]
Thommandru, B. [4 ]
Turk, R. [4 ]
Stein, M. [1 ,2 ]
Zittel, T. [1 ,2 ]
Woodley, J. [4 ]
Schubert, M. [4 ]
Volk, H. D. [1 ,2 ,3 ]
Schmueck-Henneresse, M. [1 ,2 ,3 ]
Jacobi, A. [4 ]
Reinke, P. [1 ,2 ,3 ]
Wagner, D. L. [1 ,2 ,3 ]
机构
[1] Charite, Berlin, Germany
[2] Berlin Ctr Adv Therapies BeCAT, Berlin, Germany
[3] Berlin Inst Hlth, Ctr Regenerat Therapies, Berlin, Germany
[4] Integrated DNA Technol Inc, Coralville, IA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
OR06
引用
收藏
页码:A4 / A4
页数:1
相关论文
共 44 条
  • [31] Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant
    Khoury, Ruby
    Grimley, Michael S.
    Nelson, Adam S.
    Leemhuis, Tom
    Cancelas, Jose A.
    Cook, Eleanor
    Wang, YunZu
    Heyenbruch, Daria
    Bollard, Catherine M.
    Keller, Michael D.
    Hanley, Patrick J.
    Lutzko, Carolyn
    Pham, Giang
    Davies, Stella M.
    Rubinstein, Jeremy D.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2024, 24 (09) : 1634 - 1643
  • [32] Non-viral ex vivo transduction of human hepatocyte cells to express factor VIII using a human ribosomal DNA-targeting vector
    Liu, X.
    Liu, M.
    Xue, Z.
    Pan, Q.
    Wu, L.
    Long, Z.
    Xia, K.
    Liang, D.
    Xia, J.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (02) : 347 - 351
  • [33] Improved engraftment of human peripheral blood mononuclear cells in NOG MHC double knockout mice generated using CRISPR/Cas9
    Ka, Yuyo
    Katano, Ikumi
    Nishinaka, Eiko
    Welcker, Jochen
    Mochizuki, Misa
    Kawai, Kenji
    Goto, Motohito
    Tomiyama, Kayo
    Ogura, Tomoyuki
    Yamamoto, Taichi
    Ito, Mamoru
    Ito, Ryoji
    Takahashi, Riichi
    IMMUNOLOGY LETTERS, 2021, 229 : 55 - 61
  • [34] A non-viral CRISPR/Cas9 gene-editing approach to express anti-HIV broadly-neutralizing antibodies in human B cells for HIV immunotherapy
    Doms, J.
    Fournier, C.
    Gosseye, A.
    Godot, V.
    Fenwick, C.
    Levy, Y.
    Pantaleo, G.
    Galy, A.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A158 - A158
  • [35] Enhanced Engineering of Chimeric Antigen Receptor (CAR)-Modified T Cells Using Non-Viral Sleeping Beauty-Mediated Transposition From Minicircle Vectors
    Monjezi, R.
    Miskey, C.
    Gogishvili, T.
    Einsele, H.
    Ivics, Z.
    Hudecek, M.
    BONE MARROW TRANSPLANTATION, 2016, 51 : S320 - S320
  • [36] High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA
    Oh, Soyoung A. A.
    Senger, Kate
    Madireddi, Shravan
    Akhmetzyanova, Ilseyar
    Ishizuka, Isabel E. E.
    Tarighat, Somayeh
    Lo, Jerry H. H.
    Shaw, David
    Haley, Benjamin
    Rutz, Sascha
    JOURNAL OF EXPERIMENTAL MEDICINE, 2022, 219 (05):
  • [37] PRGN-3005 UltraCAR-T™: multigenic CAR-T cells generated using non-viral gene delivery and rapid manufacturing process for the treatment of ovarian cancer
    Chan, Tim
    Chakiath, Marion
    Shepard, Lindsey
    Metenou, Simon
    Carvajal-Borda, Fernando
    Velez, Jose
    Govekung, Adeline
    Plummer, Jacques
    Poortman, Carol
    Kamineny, Padma
    Ma, Xiaohong
    Shah, Rutul R.
    Disis, Mary L.
    Sabzevari, Helen
    CANCER RESEARCH, 2020, 80 (16)
  • [38] Sleeping Beauty meets CRISPR/Cas9: Engineering of CART cells with enhanced therapeutic index using single-step, fully non-viral gene-transfer and genome-editing
    Monjezi, R.
    Miskey, C.
    Grueso, E.
    Mades, A.
    Einsele, H.
    Ivics, Z.
    Hudecek, M.
    HUMAN GENE THERAPY, 2017, 28 (12) : A33 - A33
  • [39] Safety and efficacy of CRISPR-based non-viral PD1 locus specifically integrated anti-CD19 CAR-T cells in patients with relapsed or refractory Non-Hodgkin's lymphoma: a first-in- human phase I study
    Hu, Yongxian
    Zu, Cheng
    Zhang, Mingming
    Wei, Guoqing
    Li, Wei
    Fu, Shan
    Hong, Ruimin
    Zhou, Linghui
    Wu, Wenjun
    Cui, Jiazhen
    Wang, Dongrui
    Du, Bing
    Liu, Mingyao
    Zhang, Jiqin
    Huang, He
    ECLINICALMEDICINE, 2023, 60
  • [40] CRISPR-Cas12a gene editing with linear single-stranded DNA repair templates with end modifications enables highly efficient knock-ins of therapeutic transgenes in primary human T cells
    Nitulescu, A. M.
    Du, W.
    Glaser, V.
    Kath, J.
    Wagner, D. L.
    HUMAN GENE THERAPY, 2024, 35 (3-4) : A281 - A282