Design, Synthesis, and Anticancer Activity of Bis-isoxazole Incorporated Benzothiazole Derivatives

被引：2

作者：

Cherukumalli, Purna Koteswara Rao ^{[1
]}

Tadiboina, Bhaskara Rao ^{[1
]}

Gulipalli, Kali Charan ^{[1
]}

Bodige, Srinu ^{[1
]}

Gangarapu, Kiran ^{[2
]}

Sridhar, Gattu ^{[3
]}

机构：

[1] Koneru Lakshmaiah Educ Fdn, Dept Chem, Guntur 522502, Andhra Pradesh, India

[2] Anurag Grp Inst, Sch Pharm, Medchal 500088, Telangana, India

[3] Kakatiya Inst Technol & Sci, Dept Chem, Warangal 506015, Andhra Pradesh, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 10期

关键词：

benzothiazole; isoxazole; anticancer activity; ANTITUMOR;

D O I：

10.1134/S1070363220100229

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel series of bis-isoxazole incorporated benzothiazole derivatives has been designed and synthesized. Molecular structures of the compounds have been confirmed by H-1 and C-13 NMR, and mass spectra. All products have been tested for their in vitro anticancer activity against breast MCF-7 and MDA MB-231, lungs A549, and prostate DU-145 cancer cell lines using the MTT assay and etoposide as a standard drug. Most of the compounds have demonstrated good to moderate activity, and some of those have exhibited more potent activity than etoposide.

引用

页码：1981 / 1989

页数：9

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