Engineered spider silk-based 2D and 3D materials prevent microbial infestation

被引:35
|
作者
Kumari, Sushma [1 ]
Lang, Gregor [1 ,2 ]
DeSimone, Elise [1 ]
Spengler, Christian [3 ]
Trossmann, Vanessa T. [1 ]
Luecker, Susanne [4 ]
Hudel, Martina [5 ]
Jacobs, Karin [3 ]
Kraemer, Norbert [5 ]
Scheibel, Thomas [1 ,6 ,7 ,8 ,9 ,10 ]
机构
[1] Univ Bayreuth, Fac Engn Sci, Dept Biomat, Prof Rudiger Bormann Str 1, D-95447 Bayreuth, Germany
[2] Univ Bayreuth, Fac Engn Sci, Biopolymer Proc Grp, Ludwig Thoma Str 36A, D-95447 Bayreuth, Germany
[3] Saarland Univ, Dept Expt Phys, D-66123 Saarbrucken, Germany
[4] Saarland Univ, Ctr Biophys, D-66123 Saarbrucken, Germany
[5] Justus Liebig Univ Giessen, Med Ctr Giessen & Marburg, Dept Paediat Dent, Med Ctr Dent, Schlagenzahl 14, D-35392 Giessen, Germany
[6] Justus Liebig Univ Giessen, Inst Med Microbiol, Schubertstr 81, D-35392 Giessen, Germany
[7] Bayreuth Ctr Mat Sci & Engn BayMAT, Bayreuth, Germany
[8] Bavarian Polymer Inst BPI, Wurzburg, Germany
[9] Bayreuth Ctr Colloids & Interfaces BZKG, Bayreuth, Germany
[10] Univ Bayreuth, Bayreuth Ctr Mol Biosci BZMB, Univ Str 30, D-95447 Bayreuth, Germany
关键词
CELL FORCE SPECTROSCOPY; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANCE; BIOMATERIALS; INFECTION; COATINGS; PROTEINS; POLYMERS; BIOFILMS; ADHESION;
D O I
10.1016/j.mattod.2020.06.009
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Biofilm formation, especially of antimicrobiotic-resistant microbial strains, are a major problem in health care. Therefore, there is great interest in developing advanced materials that are selectively inhibiting microbial adhesion to surfaces, but at the same time promoting mammalian cell growth. In nature, some spider silks have evolved to repel microbes, a feature that could be used in biomaterials. To unravel how microbe repellence can be achieved in engineered spider silk, different recombinant spider silk proteins based on the consensus sequences of Araneus diadematus dragline silk proteins (fibroin 3 and 4) were processed into 2D-patterned films and 3D-hydrogels. Strikingly, protein structure characteristics on the nanoscale are the basis for the detected microbe-repellence. Designed spider silk materials promoted mammalian cell attachment and proliferation while inhibiting microbial infestation, demonstrating the great potential of these engineered spider silk-based materials as bio-selective microbial-resistant coatings in biomedical as well as technical applications.
引用
收藏
页码:21 / 33
页数:13
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