Immigration accounts for nearly half of the U.S. population growth in the past 20 years, and this trend is expected to continue. The purpose of this study is to examine the relationship between demographics, resilience, life satisfaction, and psychological well-being among Irish immigrants. Employing a cross-sectional design, a sample of 100 Irish immigrants completed the Demographic and Migration Questionnaire, the Resilience Scale, the Migration Quality of Life Scale, and the General Well-Being Schedule. Hierarchical regression analyses were used to test the association of psychological well-being with demographics, resilience, and life satisfaction. Findings revealed that number of annual health care appointments, higher resilience, and greater life satisfaction were the strongest predictors of psychological well-being.