Nickel-catalyzed highly regioselective hydrocyanation of alkenes with Zn(CN)2

被引：24
|
作者：
Wang, Gaonan [1 ]
Xie, Xin [1 ]
Xu, Wei [1 ]
Liu, Yuanhong [1 ]
机构：
[1] Univ Chinese Acad Sci, Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 12期
基金：
中国国家自然科学基金;
关键词：
HYDROGEN-CYANIDE; REDUCTIVE ELIMINATION; DIPHOSPHINE LIGANDS; BITE ANGLE; OLEFINS; VINYLARENES; COMPLEXES; ALKYNES; ROLES; ACIDS;
D O I：
10.1039/c9qo00396g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first general and regioselective nickel-catalyzed hydrocyanation of terminal alkenes with Zn(CN)(2) using an air-stable and inexpensive nickel(ii) salt as the precatalyst has been established. The strategy avoids the use of the volatile and hazardous reagent HCN. Aryl/heteroaryl alkenes are effectively converted to branched nitrile derivatives, while aliphatic alkenes or active alkenes are transformed to linear nitriles with good to excellent regioselectivity.
引用
收藏
页码：2037 / 2042
页数：6
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