Unsafe SETs: histone lysine methyltransferases and cancer

被引：253

作者：

Schneider, R

Bannister, AJ

Kouzarides, T

机构：

[1] Wellcome Canc Res UK Inst, Cambridge CB2 1QR, England

[2] Dept Pathol, Cambridge CB2 1QR, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(02)02141-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.

引用

页码：396 / 402

页数：7

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