Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing

被引：19

作者：

Holmes, Anthony ^{[1
]}

Brown, Robert ^{[2
]}

Shakesheff, Kevin ^{[3
]}

机构：

[1] Natl Ctr Replacement Refinement & Reduct Anim Res, London W1B 1AL, England

[2] Univ Coll London, Royal Natl Orthopaed Hosp, UCL TREC, Inst Orthopaed, Stanmore HA7 4LP, Middx, England

[3] Univ Nottingham, Ctr Biomol Sci, Nottingham NG7 2RD, England

来源：

REGENERATIVE MEDICINE | 2009年 / 4卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

3Rs; alternative; animal model; in vitro; NC3Rs; regenerative medicine; replacement; safety testing; stem cells; tissue engineering; LYMPH-NODE ASSAY; IN-VITRO APPROACH; SKIN SENSITIZATION; INSULIN-SECRETION; AIRWAY WALL; BRONCHOALVEOLAR LAVAGE; BRONCHIAL EPITHELIUM; RESPIRATORY-TRACT; CONSUMER SAFETY; CELL LINE;

D O I：

10.2217/RME.09.26

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The focus for the rapid progress in the field of tissue engineering has been the clinical potential of the technology to repair, replace, maintain or enhance the function of a particular tissue or organ. However, tissue engineering has much wider applicability in basic research and safety testing, which is often not recognized owing to the clinical focus of tissue engineers. Using examples from a recent National Centre for the Replacement, Refinement and Reduction of Animals in Research/Biotechnology and Biological Sciences Research Council symposium, which brought together tissue engineers and scientists from other research communities, this review highlights the potential of tissue engineering to provide scientifically robust alternatives to animals to address basic research questions and improve drug and chemical development in the pharmaceutical and chemical industries.

引用

页码：579 / 592

页数：14

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