Effects of oxidative and nitrosative stress in cytotoxicity

被引：19
|
作者：
Wink, DA [1 ]
Miranda, KM [1 ]
Espey, MG [1 ]
机构：
[1] NCI, Radiat Biol Branch, NIH, Bethesda, MD 20892 USA
来源：
SEMINARS IN PERINATOLOGY | 2000年 / 24卷 / 01期
关键词：
D O I：
10.1016/S0146-0005(00)80049-X
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Nitric oxide is a key bioregulatory agent in a wide variety of biological processes, yet it also can have cytotoxic properties. This dichotomy raises the question of how this potentially toxic species can be involved in so many fundamental physiological processes. This articles discusses how the chemistry of nitric oxide might pertain to its observed biology as it relates to oxidative and nitrosative stress in different mechanisms of cytotoxicity.
引用
收藏
页码：20 / 23
页数：4
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