New steroidal saponins from Agave lophantha Schiede and their pharmacological evaluation

被引：0
|
作者：
Abdel-Khalik, SM
Miyase, T
Melek, FR [1 ]
El-Shabraway, OA
Mahmoud, II
Mina, SA
机构：
[1] Natl Res Ctr, Chem Nat Prod Dept, Dokki, Egypt
[2] Helwan Univ, Dept Pharmacognosy, Fac Pharm, Giza, Egypt
[3] Univ Shizuoka, Sch Pharmaceut Sci, Shizuoka, Japan
[4] Natl Res Ctr, Dept Pharmacol, Cairo, Egypt
来源：
PHARMAZIE | 2002年 / 57卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The structures of one new monodesmosidic spirostanoside and one new bisdesmosidic furanostanol glycoside isolated from leaves of Agave lophantha Schiede have been determined by means of spectroscopic and chemical methods as (25R)-5beta-spirostan-3beta-ol-3-O-(beta-D-apiofuranosyl(1-->4)[beta-D-glucopyranosyl(1-->3)[beta-D-glucopyranosyl(1-->2)]beta-D-galactopyranoside} and 26-O-beta-D-glucopyranosyl(25R)-5beta-furost-20(22)-ene-3beta,26-diol-3-O-{beta-D-xylopyranosyl(1-->3)-[beta-D-glucopyranosyl(1 --> 2)]beta-D-galactopyranoside}, respectively. The H-1 and (CNMR)-C-13 resonances of the two compounds were assigned by NMR (H-1, C-13, HOHAHA, H-1-H-1 COSY, HMQC, HMBC, NOE difference) studies. The pharmacological activities of the saponin containing fraction are discussed.
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收藏
页码：562 / 566
页数：5
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