Evaluation of Estrogenic Activity of Cadmium to Mice in Organic and Molecular Level

被引：0

作者：

Zhou, Qiaoqiao ^{[1
]}

Mu, Wen ^{[1
]}

Yang, Xue ^{[1
]}

Zhang, Can ^{[1
]}

Hu, Xiaojing ^{[1
]}

He, Zhen ^{[1
]}

Xiong, Li ^{[1
]}

Liu, Deli ^{[1
]}

机构：

[1] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Coll Life Sci, Wuhan 430079, Peoples R China

来源：

2010 4TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING (ICBBE 2010) | 2010年

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

cadmium; uterine and ovary weight; ERa; ER beta; semiquantitative RT-PCR; RECEPTOR-BETA; DOWN-REGULATION; ER-ALPHA; PROLIFERATION; EXPRESSION; CANCER; OVARY;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Cadmium, as an inorganic pollutant, its toxic effects on mammals were widely studied, while less attention was paid on its endocrine disrupting effects. In this paper, the effects of CdCl2 on mice uterine-ovary wet weight, modulation of ER (estrogen receptors) mRNA level and their relation were studied. It showed that uterus-ovary wet weight, the expression of ER alpha (alpha subtype) and ER beta (beta subtype) were of significant difference in 930 mu g/kg.bw CdCl2 dosing group compared with the control. However, only up-regulation of ER beta. was detected in 9.3 mu g/kg.bw CdCl2 dosing group. It suggested that the high expression of ER beta might protect mice from increasing of uterus-ovary wet weight. For CdCl2 estrogenic activity, the ER expression mechanism and ER-responsive elements pathway need further examination.

引用

页数：4

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