Module Strategy for Peptide Ribonucleic Acid (PRNA)-DNA and PRNA-Peptide Nucleic Acid (PNA)-DNA Chimeras: Synthesis and Interaction of Chimeras with DNA and RNA

被引：2

作者：

Uematsu, Ryohei ^{[1
]}

Inagaki, Masahito ^{[1
]}

Asai, Mitsuo ^{[1
]}

Sugai, Hiroka ^{[1
]}

Maeda, Yoshiki ^{[2
]}

Nagami, Akira ^{[2
]}

Sato, Hirofumi ^{[2
]}

Sakamoto, Seiji ^{[1
]}

Araki, Yasuyuki ^{[1
]}

Nishijima, Masaki ^{[2
]}

Inoue, Yoshihisa ^{[2
]}

Wada, Takehiko ^{[1
]}

机构：

[1] Tohoku Univ, IMRAM, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan

[2] Osaka Univ, Dept Appl Chem, 2-1 Yamada Oka, Suita, Osaka 5650871, Japan

来源：

CHEMISTRY LETTERS | 2016年 / 45卷 / 03期

关键词：

Oligonucleotide therapeutics; Module strategy; Peptide ribonucleic acid (PRNA); PNA; RECOGNITION; DUPLEX;

D O I：

10.1246/cl.151157

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Employing the module strategy based on our recent finding that the recognition behavior of peptide ribonucleic acid (PRNA) with complementary DNA/RNA is effectively controlled by the anti-to-syn orientation switching of pyrimidine nucleobase induced by borate ester formation, we designed and synthesized PRNA-DNA and PRNA-PNA-DNA chimeras. In these chimeras, both of the PRNA (or PRNA-PNA) and DNA domains recognize the complementary DNA/RNA to form a stable complex, and the PRNA domain is simultaneously expected to play the dual role of switching the recognition behavior and inhibiting hydrolysis by exonucleases. The complexation and recognition control behaviors of these chimeras with DNA and RNA have been elucidated.

引用

页码：350 / 352

页数：3

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