ACP-196 Is a Second Generation Inhibitor of Bruton Tyrosine Kinase (BTK) with Enhanced Target Specificity

被引：0
|
作者：
Harrington, Bonnie K. [1 ]
Gulrajani, Michael [2 ]
Covey, Todd [2 ]
Kaptein, Allard [3 ]
Van Lith, Bart [3 ]
Izumi, Raquel [2 ]
Hamdy, Ahmed [2 ]
Ulrich, Roger Glenn [2 ]
Byrd, John C. [4 ]
Lannutti, Brian J. [2 ]
Johnson, Amy J. [4 ]
机构：
[1] Ohio State Univ, Coll Vet Med, Columbus, OH 43210 USA
[2] Acerta Pharma, Redwood City, CA USA
[3] Acerta Pharma, Oss, Netherlands
[4] Ohio State Univ, Dept Med, Div Hematol, Columbus, OH 43210 USA
来源：
BLOOD | 2015年 / 126卷 / 23期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [41] Bruton's tyrosine kinase (BTK) as an inhibitor of the FAS/CD95 death inducing signaling complex (DISC).
    Vassilev, A
    Ozer, Z
    Navara, C
    Ghosh, S
    Zheng, Y
    Mahajan, S
    Uckun, FM
    BLOOD, 1998, 92 (10) : 601A - 601A
  • [42] Preclinical investigation of ibrutinib, a Bruton's kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes
    Wei, Li
    Su, Yu-Kai
    Lin, Chien-Min
    Chao, Tsu-Yi
    Huang, Shang-Pen
    Thanh-Tuan Huynh
    Jan, Hsun-Jin
    Whang-Peng, Jacqueline
    Chiou, Jeng-Fong
    Wu, Alexander T. H.
    Hsiao, Michael
    ONCOTARGET, 2016, 7 (43) : 69961 - 69975
  • [43] Cardiovascular adverse events associated with second generation Bruton tyrosine kinase inhibitor therapy: A systematic review and meta-analysis.
    Proskuriakova, Ekaterina
    Jasaraj, Ranjit
    Gaire, Suman
    Raut, Anuradha
    Reddy, Vijay Ketan
    Shrestha, Dhan
    Kovalenko, Iuliia
    Khosla, Paramjeet Grewal
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [44] Efficacy of Abbv-105, a Selective and Irreversible Inhibitor of Bruton's Tyrosine Kinase (BTK), in Multiple Models of Inflammation
    Goess, Christian
    Graff, Candace
    Zhang, Ting Ting
    Preston, Gregory
    McCarthy, Richard
    Perham, Matthew
    Loud, Jacqueline
    Harris, Christopher M.
    Murdock, Sara
    Sampson, Erik
    Hoemann, Michael
    Friedman, Michael
    Talanian, Robert
    Edmunds, Jeremy
    Long, Andrew
    ARTHRITIS & RHEUMATOLOGY, 2015, 67
  • [45] Cardiovascular Adverse Events (CVAE) Associated With Second Generation Bruton Tyrosine Kinase (BTK) Inhibitor (BTKi) Therapy in Patients With Chronic Lymphocytic Leukemia (CLL): A Systematic Review and Meta-Analysis
    Proskuriakova, Ekaterina
    Shrestha, Dhan
    Jasaraj, Ranjit
    Mercado, Gustavo Espinoza
    Wortstman, Josh
    Kovalenko, Iulia
    Khosla, Pam
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S327 - S328
  • [46] New European Approvals: Brexucabtagene autoleucel for refractory mantle cell lymphoma after Bruton tyrosine kinase (BTK) inhibitor
    Rousseau, Adrien
    Thieblemont, Catherine
    BULLETIN DU CANCER, 2021, 108 (02) : 142 - 144
  • [47] Remibrutinib, a novel Bruton tyrosine kinase inhibitor, exhibits improved target selectivity and potency in vitro
    Pulz, R.
    Angst, D.
    Eichlisberger, D.
    Cenni, B.
    MULTIPLE SCLEROSIS JOURNAL, 2022, 28 (3_SUPPL) : 749 - 749
  • [48] Arrhythmogenic Ventricular Remodeling by Next-Generation Bruton's Tyrosine Kinase Inhibitor Acalabrutinib
    Zhao, Yanan
    Chakraborty, Praloy
    Tomassetti, Julianna
    Subha, Tasnia
    Masse, Stephane
    Thavendiranathan, Paaladinesh
    Billia, Filio
    Lai, Patrick F. H.
    Abdel-Qadir, Husam
    Nanthakumar, Kumaraswamy
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (11)
  • [49] RETRACTED: ACP-196, an orally bioavailable covalent selective inhibitor of Btk, modulates the innate tumor microenvironment, exhibits antitumor efficacy and enhances gemcitabine activity in pancreatic cancer (Retracted Article)
    Lannutti, Brian J.
    Gulrajani, Michael
    Krantz, Fanny
    Bibikova, Elena
    Covey, Todd
    Jessen, Katti
    Rothbaum, Wayne
    Johnson, David M.
    Ulrich, Roger
    CANCER RESEARCH, 2015, 75
  • [50] Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor
    MacGlashan, Donald, Jr.
    Honigberg, Lee A.
    Smith, Ashley
    Buggy, Joseph
    Schroeder, John T.
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2011, 11 (04) : 475 - 479
12345