Liposomes - Opportunities in drug delivery

被引：225
|
作者：
Allen, TM
机构：
[1] Department of Pharmacology, University of Alberta, Edmonton
来源：
DRUGS | 1997年 / 54卷 / Suppl 4期
关键词：
D O I：
10.2165/00003495-199700544-00004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Liposomal drug delivery systems markedly alter the biodistribution of their associated drugs by delaying drug clearance, retarding drug metabolism, decreasing the volume of distribution, and shifting the distribution in favour of diseased tissues with increased capillary permeability. This increases the therapeutic indices of the associated drugs, by increasing the drug concentration in solid tumours and regions of infection, and reducing the drug concentration in normal tissues, Three liposomal formulations have been approved for clinical use.
引用
收藏
页码：8 / 14
页数：7
相关论文
共 50 条
  • [41] Overcoming barriers by local drug delivery with liposomes
    Antimisiaris, S. G.
    Marazioti, A.
    Kannavou, M.
    Natsaridis, E.
    Gkartziou, F.
    Kogkos, G.
    Mourtas, S.
    ADVANCED DRUG DELIVERY REVIEWS, 2021, 174 : 53 - 86
  • [42] Stimuli-responsive liposomes for drug delivery
    Lee, Y.
    Thompson, D. H.
    WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2017, 9 (05)
  • [43] PH-sensitive liposomes in drug delivery
    Paliwal, Shivani Rai
    Paliwal, Rishi
    Vyas, Suresh P.
    RSC Smart Materials, 2013, 1 (01): : 80 - 93
  • [44] The application of glycosylated liposomes in targeted drug delivery
    Wen, Jing
    Xu, Junshuang
    Hong, Min
    Li, Wei
    Li, Tie
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2025, 105
  • [45] Plasmon resonant liposomes for controlled drug delivery
    Knights-Mitchell, Shellie S.
    Romanowski, Marek
    COLLOIDAL NANOPARTICLES FOR BIOMEDICAL APPLICATIONS X, 2015, 9338
  • [46] Lysolipid containing liposomes for transendothelial drug delivery
    Tilen Koklic
    Janez trancar
    BMC Research Notes, 5 (1)
  • [47] Liposomes in topical ophthalmic drug delivery: an update
    Agarwal, Renu
    Iezhitsa, Igor
    Agarwal, Puneet
    Nasir, Nurul Alimah Abdul
    Razali, Norhafiza
    Alyautdin, Renad
    Ismail, Nafeeza Mohd
    DRUG DELIVERY, 2016, 23 (04) : 1075 - 1091
  • [48] Folate-targeted liposomes for drug delivery
    Lee, RJ
    Low, PS
    JOURNAL OF LIPOSOME RESEARCH, 1997, 7 (04) : 455 - 466
  • [49] Recent Applications of Liposomes in Ophthalmic Drug Delivery
    Mishra, Gyan P.
    Bagui, Mahuya
    Tamboli, Viral
    Mitra, Ashim K.
    JOURNAL OF DRUG DELIVERY, 2011, 2011
  • [50] Peptide functionalized liposomes for targeted drug delivery
    Tu, RS
    Tirrell, MV
    Mohanty, K
    BIOPHYSICAL JOURNAL, 2001, 80 (01) : 414A - 415A
12345