HMGB1 in Hormone-Related Cancer: a Potential Therapeutic Target

被引：27

作者：

Srinivasan, Madhuwanti ^{[1
]}

Banerjee, Souresh ^{[1
]}

Palmer, Allison ^{[1
]}

Zheng, Guoxing ^{[1
]}

Chen, Aoshuang ^{[1
]}

Bosland, Maarten C. ^{[2
]}

Kajdacsy-Balla, Andr ^{[2
]}

Kalyanasundaram, Ramaswamy ^{[1
]}

Munirathinam, Gnanasekar ^{[1
,3
]}

机构：

[1] Univ Illinois, Coll Med, Dept Biomed Sci, Rockford, IL 61107 USA

[2] Univ Illinois, Dept Pathol, Chicago, IL USA

[3] Univ Illinois, Ctr Canc, Chicago, IL USA

来源：

HORMONES & CANCER | 2014年 / 5卷 / 03期

关键词：

MOBILITY GROUP BOX-1; END-PRODUCTS RAGE; DNA-BINDING; CELL-DEATH; PROGESTERONE-RECEPTOR; CHROMATIN PROTEINS; MESSENGER-RNA; LETHAL SEPSIS; CALF-THYMUS; BETA-CELLS;

D O I：

10.1007/s12672-014-0175-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High-mobility group box 1 (HMGB1) is a dynamic nuclear protein participating in transcription, chromatin remodelling, and DNA recombination and repair processes. Accumulating evidence indicates that its function now extends beyond the nucleus, notably its extracellular role in inflammation. HMGB1 is implicated as a late mediator of sepsis and is also believed to promote atherosclerosis and other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. Interestingly, deregulation of HMGB1 is shown to be associated with the hallmarks of cancer development. Moreover, several clinical studies have shown that HMGB1 is a promising biomarker for a variety of cancer types. In this review, we provide novel insights into the role and mechanisms of HMGB1, in particular, to hormone-related cancers and its potential to serve as a therapeutic target.

引用

页码：127 / 139

页数：13

共 50 条

[21] Parathyroid Hormone-Related Protein: Potential Therapeutic Target for Melanoma Invasion and Metastasis
Huang, Dao Chao
Yang, Xian Fang
Ochietti, Benoit
Fadhil, Ibtihal
Camirand, Anne
Kremer, Richard
ENDOCRINOLOGY, 2014, 155 (10) : 3739 - 3749
[22] HMGB1 as a late mediator and therapeutic target in sepsis
Yang, H
Czura, CJ
Tracey, KJ
SHOCK, 2004, 21 : 124 - 124
[23] Extracellular HMGB1 as a therapeutic target in inflammatory diseases
Andersson, Ulf
Yang, Huan
Harris, Helena
EXPERT OPINION ON THERAPEUTIC TARGETS, 2018, 22 (03) : 263 - 277
[24] HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection
Andersson, Ulf
Tracey, Kevin J.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 : 139 - 162
[25] HMGB1 as a therapeutic target of focal cortical dysplasia
Zheng, Yang
Wang, Yi
Ding, Mei-Ping
Chen, Zhong
NEUROLOGY, 2021, 96 (15)
[26] HMGB1 protein as a novel target for cancer
Tripathi, Alok
Shrinet, Kriti
Kumar, Arvind
TOXICOLOGY REPORTS, 2019, 6 : 253 - 261
[27] HMGB1, a potential new target for mesothelioma therapy
Jube, Sandro
Rivera, Zeyana
Gaudino, Giovanni
Pass, Harvey I.
Bianchi, Marco E.
Carbone, Michele
Yang, Haining
CANCER RESEARCH, 2011, 71
[28] HMGB1: a potential new target for tendinopathy treatment
Lu, Panpan
Li, Yingjuan
Dai, Guangchun
Zhang, Yuanwei
Shi, Liu
Zhang, Ming
Wang, Hao
Rui, Yunfeng
CONNECTIVE TISSUE RESEARCH, 2023, 64 (04) : 362 - 375
[29] The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications
Wu, Lei
Yang, Lili
ONCOLOGY LETTERS, 2018, 15 (05) : 6799 - 6805
[30] Non-histone nuclear factor HMGB1 as a therapeutic target in colorectal cancer
Ohmori, Hitoshi
Luo, Yi
Kuniyasu, Hiroki
EXPERT OPINION ON THERAPEUTIC TARGETS, 2011, 15 (02) : 183 - 193

← 1 2 3 4 5 →