TARGETING WILDTYPE IL-2 TO CD8 T CELLS INDUCES POTENT ANTI-TUMOR IMMUNE RESPONSES AND DECREASES IL-2 MEDIATED TOXICITY

被引:0
|
作者
Ramasamy, Selvi [1 ]
Nardozzi, Joanathan [1 ]
Boi, Shannon [1 ]
Swain, Joanna [1 ]
Coyle, Anthony [1 ]
Gulla, Stefano [1 ]
机构
[1] Repertoire Immune Med, Cambridge, MA USA
关键词
D O I
10.1136/jitc-2022-SITC2022.1098
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1098
引用
收藏
页码:A1141 / A1141
页数:1
相关论文
共 50 条
  • [31] PEGylated IL-2 with enhanced anti-tumor efficacy and safety profile
    Song, Yuntao
    Li, Hui
    Zhang, Wei
    Fu, Dayan
    Xu, Meng
    CANCER RESEARCH, 2022, 82 (12)
  • [32] Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2:: Coordination of dendritic and CD8+ cell responses
    Murphy, WJ
    Welniak, L
    Back, T
    Hixon, J
    Subleski, J
    Seki, N
    Wigginton, JM
    Wilson, SE
    Blazar, BR
    Malyguine, AM
    Sayers, TJ
    Wiltrout, RH
    JOURNAL OF IMMUNOLOGY, 2003, 170 (05): : 2727 - 2733
  • [33] IL-2 induces soluble Fas in PBMC cultures of HIV+ patients with high Fas expressing CD8 T cells
    Hosaka, N
    Tateyama, M
    Soc, T
    Pahwa, S
    FASEB JOURNAL, 1998, 12 (04): : A294 - A294
  • [34] Delivery of IL-2 to the T Cell Surface Through Phosphatidylserine Permits Robust Expansion of CD8 T Cells
    MacDonald, Alana
    Lam, Brandon
    Lin, John
    Ferrall, Louise
    Kung, Yu Jui
    Tsai, Ya Chea
    Wu, T. -C.
    Hung, Chien-Fu
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [35] GM-CSF/IL-2 fusion transgene is more potent than GM-CSF and IL-2 in combination and is dependent upon CD8 and NK cells for antitumor effect
    Stagg, J
    Bouganim, N
    Galipeau, J
    MOLECULAR THERAPY, 2004, 9 : S133 - S133
  • [36] An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo
    D'Souza, WN
    Lefrançois, L
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (11) : 2977 - 2985
  • [37] IL-2 production by activated naive and effector CD8 T cells forecasts memory formation.
    Kahan, Shannon
    Bakshi, Rakesh
    Luther, Rita
    Harrington, Laurie
    Weaver, Casey
    Zajac, Allan
    JOURNAL OF IMMUNOLOGY, 2015, 194
  • [38] Tracking the in vivo history and fate of IL-2 producing CD8 T cells during memory differentiation
    Yuzefpolskiy, Yevgeniy
    Sarkar, Surojit
    Kalia, Vandana
    JOURNAL OF IMMUNOLOGY, 2019, 202 (01):
  • [39] AB248 is a CD8+T cell selective IL-2 designed for superior safety and anti-tumor efficacy
    Moynihan, Kelly D.
    Pappas, Danielle
    Park, Terrence
    Chen, Wei
    Ni, Irene
    Bessette, Paul
    Nguyen, Henry
    Liu, David
    Chin, Mike
    Lan, Ruth
    Arvey, Aaron
    Schumacher, Ton N.
    Yeung, Yik Andy
    Djuretic, Ivana
    CANCER RESEARCH, 2022, 82 (12)
  • [40] Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals
    Kim, Marie T.
    Kurup, Samarchith P.
    Starbeck-Miller, Gabriel R.
    Harty, John T.
    JOURNAL OF IMMUNOLOGY, 2016, 197 (05): : 1754 - 1761