Synthesis of new 2-[1(2H)-phthalazinon-2-yl]-acetamide and 3-[1(2H)-phthalazinon-2-yl]-propanamide derivatives as antinociceptive and anti-inflammatory agents

被引：56
|
作者：
Dogruer, DS
Kupeli, E
Yesilada, E
Sahin, MF [1 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey
[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey
来源：
ARCHIV DER PHARMAZIE | 2004年 / 337卷 / 06期
关键词：
1(2H); phthalazinone; antinociceptive; anti-inflammatory;
D O I：
10.1002/ardp.200200719
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
As a consequence of our ongoing studies on heterocyclic compounds for new antinociceptive and anti-inflammatory agents bearing lactam functional group, new 2-[1(2H)-phthalazinon-2-yl]acetamide and 3-[1(2H)-phthalazinon-2-yl]propanamide derivatives have been synthesized. Among the compounds synthesized, compound 4e was found the most active derivative in terms of antinociceptive and anti-inflammatory activities, without gastric lesions and bleeding at the given dose.
引用
收藏
页码：303 / 310
页数：8
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