Mechanisms of Action of Phytochemicals from Medicinal Herbs in the Treatment of Alzheimer's Disease

被引:74
|
作者
Kim, Mi Hye [1 ,2 ]
Kim, Sung-Hoon [3 ]
Yang, Woong Mo [1 ,2 ]
机构
[1] Kyung Hee Univ, Coll Korean Med, Seoul 130701, South Korea
[2] Kyung Hee Univ, Inst Korean Med, Seoul 130701, South Korea
[3] Kyung Hee Univ, Coll Korean Med, Canc Prevent Mat Dev Res Ctr, Seoul 130701, South Korea
基金
新加坡国家研究基金会;
关键词
Alzheimer's disease; phytochemical; medicinal herbs; drug development; AMYLOID PRECURSOR PROTEIN; NF-KAPPA-B; GINSENOSIDE RG1; BETA-SECRETASE; A-BETA; COGNITIVE IMPAIRMENT; IN-VITRO; INFLAMMATORY RESPONSE; CURCUMIN PROTECTS; OXIDATIVE STRESS;
D O I
10.1055/s-0034-1383038
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Alzheimer's disease is a chronic neurodegenerative disorder characterized by progressive dementia and deterioration of cognitive function. Although several drugs currently used for the treatment of Alzheimer's disease delay its onset and slow its progression, still there is no drug with profound disease-modifying effects. Studies aiming the treatment of this neurodegenerative disorder explore various disease mechanisms. Since antiquity, medicinal herbs have been used in traditional medicine. Recent studies suggest that the neurobiological effects of phytochemicals from medicinal herbs may contribute to clinical benefits in in vitro and in vivo models of Alzheimer's disease. This review focuses on five phytochemicals, berberine, curcumin, ginsenoside Rg1, puerarin, and silibinin, which have been mostly investigated to treat the development and progression of this neurodegenerative disorder.
引用
收藏
页码:1249 / 1258
页数:10
相关论文
共 50 条
  • [21] Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action
    Kwan, CY
    Achike, FI
    ACTA PHARMACOLOGICA SINICA, 2002, 23 (12) : 1057 - 1068
  • [23] Neuroprotective Herbs for the Management of Alzheimer's Disease
    Gregory, Julie
    Vengalasetti, Yasaswi V.
    Bredesen, Dale E.
    Rao, Rammohan V.
    BIOMOLECULES, 2021, 11 (04)
  • [24] Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer's disease: A review
    Jiang, Yingying
    Gao, Hongwei
    Turdu, Gulmira
    BIOORGANIC CHEMISTRY, 2017, 75 : 50 - 61
  • [25] Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease
    Ilina, Anastasiia
    Khavinson, Vladimir
    Linkova, Natalia
    Petukhov, Mikhael
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (08)
  • [26] A Computational In silico Approach for Identification of Indian Herbs for the Treatment of Alzheimer's Disease
    Manakadan, Asha Asokan
    Suja, Saranya Tulasidharan
    Silvipriya, K. S.
    Chithra, J.
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2015, 6 (01): : 414 - 422
  • [27] Exploring Medicinal Herbs' Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer's Disease Treatment
    Farihi, Ayoub
    Bouhrim, Mohamed
    Chigr, Fatiha
    Elbouzidi, Amine
    Bencheikh, Noureddine
    Zrouri, Hassan
    Nasr, Fahd A.
    Parvez, Mohammad Khalid
    Alahdab, Ahmad
    Ahami, Ahmed Omar Touhami
    MEDICINA-LITHUANIA, 2023, 59 (10):
  • [28] Free radical scavenging action of medicinal herbs from Mongolia
    Myagmar, BE
    Aniya, Y
    PHYTOMEDICINE, 2000, 7 (03) : 221 - 229
  • [29] Ginkgo biloba Extract in Alzheimer's Disease: From Action Mechanisms to Medical Practice
    Shi, Chun
    Liu, Jun
    Wu, Fengming
    Yew, David T.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (01): : 107 - 123
  • [30] A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease
    Li, Bohui
    Xu, Xue
    Wang, Xia
    Yu, Hua
    Li, Xiuxiu
    Tao, Weiyang
    Wang, Yonghua
    Yang, Ling
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (10) : 13501 - 13520