Relationships between cytokines and cognitive function from pre- to post-chemotherapy in patients with breast cancer

被引：11

作者：

Janelsins, Michelle C. ^{[1
,2
]}

Lei, Lianlian ^{[3
]}

Netherby-Winslow, Colleen ^{[1
]}

Kleckner, Amber S. ^{[1
,2
]}

Kerns, Sarah ^{[2
,4
]}

Gilmore, Nikesha ^{[1
,2
]}

Belcher, Elizabeth ^{[1
,2
]}

Thompson, Bryan D. ^{[1
]}

Werner, Zachary A. ^{[1
]}

Hopkins, Judith O. ^{[5
]}

Long, Joan ^{[6
]}

Cole, Sharon ^{[7
]}

Culakova, Eva ^{[1
]}

机构：

[1] Univ Rochester, Dept Surg, Support Care Canc, 265 Crittenden Blvd, Rochester, NY 14642 USA

[2] Wilmot Canc Inst, Rochester, NY 14642 USA

[3] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[4] Univ Rochester, Dept Radiat Oncol, Rochester, NY 14624 USA

[5] Southeast Clin Oncol Res Consortium SCOR, 2150 Country Club Rd Suite 200, Winston Salem, NC 27104 USA

[6] Canc Res Consortium West Michigan NCORP CRCWM, 25 Michigan St NE,Suite 3100, Grand Rapids, MI 49503 USA

[7] Dayton Clin Oncol Program, 3123 Res Blvd,Suite 150, Dayton, OH 45420 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2022年 / 362卷

基金：

美国国家卫生研究院;

关键词：

Cognition; Cytokines  cancer; Chemotherapy; Cancer-related cognitive decline (CRCD); IMPAIRMENT; CHEMOTHERAPY; MEMORY; BRAIN; INTERLEUKIN-6; PERFORMANCE; MCP-1; MANAGEMENT; CONSTRUCT; VALIDITY;

D O I：

10.1016/j.jneuroim.2021.577769

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer-related cognitive decline (CRCD) is a clinically important problem and negatively affects daily functioning and quality of life. We conducted a pilot longitudinal study from pre-to post-chemotherapy in patients with breast cancer to assess changes in inflammation and cognition over time, as well as the impact of baseline cytokine level on post-chemotherapy cognitive scores. We found that concentrations of IL-6, MCP-1, sTNFRI, and sTNFRII significantly increased in patients, while IL-1 beta significantly decreased (p < 0.05). After controlling for covariates, increases in IL-6 and MCP-1 were associated with worse executive function and verbal fluency in patients from pre-to post-chemotherapy (p < 0.05). Higher baseline IL-6 was associated with better performance on executive function and verbal fluency post chemotherapy (p < 0.05). Overall, these results suggest that chemotherapy-associated increases in cytokines/receptors is associated with worse cognitive function. Larger studies are needed to confirm these findings.

引用

页数：8

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