METAL ION-DIRECTED SYNTHESIS OF TWO MIXED-LIGAND COORDINATION POLYMERS: PROTECTIVE ACTIVITY ON THE ACUTE KIDNEY INJURY BY REDUCING THE NAGL CONTENT IN URINE

In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Cu(oba)(4-bpdb)]center dot CH3OH}(n) (1) and {[Co-3(oba)(3)(4-bpdb)(DMF)(2)]center dot 4H(2)O}(n) (2) (H(2)oba = 4,4 '-oxybis-benzoate, 4-bpdb = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene) are synthesized under solvothermal conditions. Both structures are analyzed by single crystal X-ray diffraction along with the elemental analysis. Their prevention activity on the acute kidney injury in patients with acute cerebral hemorrhage is evaluated and the protentional mechanism is revealed. Firstly, the Nagl content in urine is measured. Secondly, the inflammatory response in glomerular epithelial cells is detected by real-time RT-PCR.