Copper-Catalyzed Bromodifluoroacetylative Cyclization of Enynes

被引：26
|
作者：
Zhu, Shaoqun [1 ]
Yang, Haibo [1 ]
Jiang, Along [1 ]
Zhou, Bing [1 ]
Han, Ying [1 ]
Yan, Chaoguo [1 ]
Shi, Yaocheng [1 ]
Hou, Hong [1 ]
机构：
[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225009, Jiangsu, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 23期
基金：
中国国家自然科学基金;
关键词：
ETHYL BROMODIFLUOROACETATE; DIFLUOROALKYLATION; CONSTRUCTION; FLUORINE; ALKYNES; FLUOROALKYLATIONS; PHOSPHONATES; ELUCIDATION; BONDS; ACIDS;
D O I：
10.1021/acs.joc.0c02114
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed bromodifluoroacetylative cyclization reaction is described. The treatment of bromodifluoroacete derivatives by CuI and B(2)Pin(2) enables difluoroalkyl radical generation and triggers the radical addition/cyclization/bromination sequences. Bromodifluoroacetyl-derived ester, amide, and ketone were compatible and gave various vinyl C-Br bonds containing functionalized heterocycles in good yields.
引用
收藏
页码：15667 / 15675
页数：9
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