Preparation and Characterization of Porous Scaffolds Consisted of Hydroxyapatite, Polysaccharides and Collagen for Cartilage Tissue Engineering

被引：1

作者：

Adegawa, Takuro ^{[1
]}

Ohyabu, Yoshimi ^{[1
,2
]}

Uemura, Toshimasa ^{[2
]}

Yoshioka, Tomohiko ^{[1
]}

Shinozaki, Kazuo ^{[1
]}

Tanaka, Junzo ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Met & Ceram Sci, Meguro Ku, 2-12-1 S7-6, Tokyo 1528550, Japan

[2] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058562, Japan

来源：

BIOCERAMICS 21 | 2009年 / 396-398卷

关键词：

cartilage; scaffold; hydroxyapatite; polysaccharide; chondroitinsulfate; collagen; NANOCOMPOSITES; MATRICES; CELLS;

D O I：

10.4028/www.scientific.net/KEM.396-398.707

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Porous scaffolds, consisted of hydroxyapatite (HAp), chondroitinsulfate (ChS) and collagen, were prepared by freeze-drying technique. HAp/ChS composite particles were incorporated into a collagen matrix. Scanning electron microscope (SEM) observations showed that the porous scaffolds involved interconnected pores whose size was 80-200 mu m in diameter. The HAp/ChS particles were homogeneously distributed in the collagen matrix. Surface area of the scaffolds was increased by the incorporation of the particles. Compression tests in phosphate buffer saline indicated that the porous scaffolds had elastic property and had larger compressive modulus than the pure collagen scaffold. The porous scaffolds obtained in this study could be useful for a cartilage tissue engineering.

引用

页码：707 / 710

页数：4

共 50 条

[41] Heparinized hydroxyapatite/collagen three-dimensional scaffolds for tissue engineering
S. Teixeira
L. Yang
P. J. Dijkstra
M. P. Ferraz
F. J. Monteiro
Journal of Materials Science: Materials in Medicine, 2010, 21 : 2385 - 2392
[42] Tissue Engineering of Cartilage Using Collagen Scaffold Enriched with Plant Polysaccharides
Uday Chandrika, K.
Kacha, Sapna
Nair, Anuja S.
Jamwal, Vijayishwer S.
Sandilya, Shruti
Singh, Shashi
CARTILAGE, 2021, 13 (2_SUPPL) : 650S - 662S
[43] Controlling the processing of collagen-hydroxyapatite scaffolds for bone tissue engineering
Denys A. Wahl
Eleftherios Sachlos
Chaozong Liu
Jan T. Czernuszka
Journal of Materials Science: Materials in Medicine, 2007, 18 : 201 - 209
[44] Biomimetic porous collagen/hydroxyapatite scaffold for bone tissue engineering
Chen, Li
Wu, Zhenxu
Zhou, Yulai
Li, Linlong
Wang, Yu
Wang, Zongliang
Chen, Yue
Zhang, Peibiao
Journal of Applied Polymer Science, 2017, 134 (37):
[45] Porous hydroxyapatite-chitosan scaffolds for tissue engineering: experimental characterization and molecular dynamics simulation
Zardosht, Hojjatollah
Mosleh-Shirazi, Sareh
Heidari, Fatemeh
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 2025, 131 (02):
[46] Biomimetic porous collagen/hydroxyapatite scaffold for bone tissue engineering
Chen, Li
Wu, Zhenxu
Zhou, Yulai
Li, Linlong
Wang, Yu
Wang, Zongliang
Chen, Yue
Zhang, Peibiao
JOURNAL OF APPLIED POLYMER SCIENCE, 2017, 134 (37)
[47] Preparation and characterization of collagen-hydroxyapatite composite used for bone tissue engineering scaffold
Liu, LR
Zhang, LH
Ren, BZ
Wang, FJ
Zhang, QQ
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY, 2003, 31 (04): : 435 - 448
[48] Novel porous aortic elastin and collagen scaffolds for tissue engineering
Lu, QJ
Ganesan, K
Simionescu, DT
Vyavahare, NR
BIOMATERIALS, 2004, 25 (22) : 5227 - 5237
[49] Comparison of three types of chondrocytes in collagen scaffolds for cartilage tissue engineering
Zhang, Lu
Spector, Myron
BIOMEDICAL MATERIALS, 2009, 4 (04)
[50] Novel phase separated polycaprolactone/collagen scaffolds for cartilage tissue engineering
Munir, N.
Callanan, A.
BIOMEDICAL MATERIALS, 2018, 13 (05)

← 1 2 3 4 5 →