Caffeine vehiculation into alpha-zirconium phosphate: a multifunctional intercalation product and its application for modified topical release

被引：3
|
作者：
Bastianini, M. [1 ]
Sisani, M. [1 ]
Petracci, A. [1 ]
Di Guida, I. [1 ]
Faffa, C. [1 ]
Cardellini, F. [1 ]
机构：
[1] Prolabin & Tefarm Srl, R&D Dept, Via Acciaio 9, I-06134 Perugia, Italy
来源：
MATERIALS ADVANCES | 2021年 / 2卷 / 04期
关键词：
NANOPLATELETS; DRUG; MECHANISMS; ADSORPTION; DELIVERY; ACID; SKIN;
D O I：
10.1039/d0ma00729c
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Caffeine possesses many important biological effects and is known to be a model drug for topical applications. Zirconium phosphate (ZrP) is able to intercalate basic molecules and it is an effective drug carrier. The vehiculation of drugs in lamellar solids can finely tune their properties: in this article the first intercalation of caffeine in ZrP is reported. The intercalation strategy was designed on the basis of the chemical properties of the host and guest, and the synthesized product was fully chemically-physically characterized and tested for topical release using the Franz cell diffusion system.
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页码：1313 / 1319
页数：7
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