Dietary corn fractions reduce atherogenesis in low-density lipoprotein receptor knockout mice

被引:5
|
作者
Masisi, Kabo [1 ,2 ,3 ,4 ]
Le, Khuong [2 ,4 ]
Ghazzawi, Nora [2 ,4 ]
Moghadasian, Mohammed H. [2 ,4 ]
Beta, Trust [1 ,3 ]
机构
[1] Univ Manitoba, Dept Food Sci, 250 Ellis Bldg, Winnipeg, MB R3T 2N2, Canada
[2] Univ Manitoba, Dept Human Nutr Sci, 209 Human Ecol Bldg, Winnipeg, MB R3T 2N2, Canada
[3] Univ Manitoba, Richardson Ctr Funct Foods & Nutraceuticals, 196 Innovat DriveSmart Pk, Winnipeg, MB R3C 6C5, Canada
[4] St Boniface Gen Hosp, Res Ctr, Canadian Ctr Agri Food Res Hlth & Med, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada
基金
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词
Corn fractions; LDL-receptor knockout mice; Lipid profile; Atherosclerotic lesions; CORONARY-HEART-DISEASE; WHOLE-GRAIN INTAKE; INSULIN-RESISTANCE; PHENOLIC-ACIDS; WHEAT-GERM; RISK; CHOLESTEROL; ATHEROSCLEROSIS; BRAN; SERUM;
D O I
10.1016/j.nutres.2016.12.005
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Accumulating evidence has suggested that intake of whole grains is a protective factor against pathogenesis of coronary artery disease. The exact mechanisms, however, are still not clearly understood. In this study, we hypothesized that adequate intake of corn fractions (aleurone, endosperm and germ) can modify lipid profiles in relation to atherosclerotic lesion development in low-density lipoprotein receptor knockout (LDLr-KO) mice. The purpose of the present study was to investigate the potential cardiovascular benefits of corn fractions in LDLr-KO mice through a number of biomarkers including lipid profile, and morphologic and morphometrical analysis of atherosclerotic lesions in aortic root. Four groups of male LDLr-KO mice were fed with the experimental diets supplemented with (3 treated) or without (control) 5% (wt/wt) of each of corn fractions for 10 weeks. All diets were supplemented with 0.06% (wt/wt) cholesterol. Compared with mice in the control group, atherosclerotic lesions in the aortic roots were significantly reduced (P = .003) in the mice that were fed diet supplemented with aleurone and germ fractions. This effect was associated with significant reductions in plasma total (P = .02) and LDL (P = .03) cholesterol levels, and an increase in fecal cholesterol excretion (P = .04). Furthermore, abdominal fat mass was significantly reduced by consumption of aleurone (P = .03). In summary, the consumption of aleurone and germ may help attenuate atherosclerosis by reducing plasma total and LDL cholesterol levels. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:87 / 96
页数:10
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