Synthesis and Antiproliferative Activity of Coumarin-Estrogen Conjugates against Breast Cancer Cell Lines

被引：36

作者：

Musa, Musiliyu A. ^{[1
]}

Khan, M. Omar F. ^{[2
]}

Cooperwood, John S. ^{[3
]}

机构：

[1] Florida A&M Univ, Coll Arts & Sci, Dept Chem, Tallahassee, FL 32307 USA

[2] SW Oklahoma State Univ, Coll Pharm, Weatherford, OK USA

[3] Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 02期

关键词：

Coumarin; 17; beta-estradiol; Conjugates; Cytotoxicity; Antiproliferative activity and Breast cancer; RECEPTOR BINDING-AFFINITY; BIOLOGICAL EVALUATION; TETRAZOLIUM ASSAY; DIVERSE PANEL; ESTRADIOL; DERIVATIVES; AGENTS; 4-HYDROXYCOUMARIN; 1,2-BENZOPYRONE; CYTOTOXICITY;

D O I：

10.2174/157018009787582624

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses and cytotoxic activity of coumarin-estrogen conjugates are described. In vitro results indicated that conjugates 10, 11 and 13 show growth inhibitory activities at 5-dose concentration (100, 10, 1, 0.1, 0.01 mu M) against the following NCI-7- human breast cancer cell lines: BT-549, HS 578T, MCF 7, MDA-MB-231/ATCC, MDA-MB-435, NCI/ADR-RES, and thus serve as new leads for further development of antibreast cancer agent.

引用

页码：133 / 138

页数：6

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