Driven Hematopoietic Differentiation of Embryonic Stem Cells: Epigenetic Perspectives

被引：1

作者：

Tesarova, Lenka ^{[1
]}

Stejskal, Stanislav ^{[1
]}

Koutna, Irena ^{[1
]}

机构：

[1] Masaryk Univ, FI, Ctr Biomed Image Anal, Brno 60200, Czech Republic

来源：

CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 11期

关键词：

Epigenetic; stem cells; pluripotency; cell differentiation; hematopoietic development; POLYCOMB GROUP PROTEINS; TRANSCRIPTIONAL REGULATORY CIRCUITRY; DNA METHYLTRANSFERASE 3A; DE-NOVO METHYLATION; MOUSE ES CELLS; SELF-RENEWAL; HISTONE DEACETYLASE; PROGENITOR CELLS; DEVELOPMENTAL REGULATORS; GENE-EXPRESSION;

D O I：

10.2174/13816128113199990524

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed.

引用

页码：1674 / 1686

页数：13

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