Mathematical Modeling of Functioning of the p53-Mdm2 Protein System

被引：3
|
作者：
Voropaeva, O. F. [1 ]
Shokin, Yu I. [1 ]
Nepomnyashchikh, L. M. [2 ]
Senchukova, S. R. [2 ]
机构：
[1] Russian Acad Sci, Siberian Div, Inst Computat Technol, Novosibirsk, Russia
[2] Russian Acad Med Sci, Siberian Div, Res Inst Reg Pathol & Pathomorphol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 02期
关键词：
p53-dependent apoptosis; p53-Mdm2; network; mathematical simulation;
D O I：
10.1007/s10517-014-2548-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Mathematical simulation of the time course of p53 and Mdm2 protein concentrations during their interactions was carried out. The system states corresponding to threatened uncontrolled apoptotic cell death accelerating aging processes and to situation with hypersuppression of p53-dependent apoptosis fraught with high risk of cancer were modeled. New data indicate the possibility of description (within the framework of mathematical model used in the study) of the p53 and Mdm2 proteins feedback mechanism, which could guarantee adequate reaction to serious DNA damage.
引用
收藏
页码：291 / 294
页数：4
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