A probabilistic approach to compact steady-state kinetic equations for enzymic reactions

被引：5
|
作者：
Malygin, Ernst G.
Hattman, Stanley
机构：
[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA
[2] State Res Ctr Virol & Biotechnol Vector, Inst Mol Biol, Novosibirsk 630559, Russia
来源：
JOURNAL OF THEORETICAL BIOLOGY | 2006年 / 242卷 / 03期
关键词：
reaction graph; scheme simplification; probability;
D O I：
10.1016/j.jtbi.2006.03.022
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We describe a method for deriving kinetic equations based on the simplification of a complex graphical scheme of steady-state enzymic reactions to one that is comprised of an unbranched pathway. It entails compressing unbranched multi-step sequences into one step, and fusing some graph nodes into a single node. The final form of the equations is compact and well structured, and it simplifies the choice of independent kinetic parameters. The approach is illustrated by an analysis of representative two- and three-substrate reactions. (c) 2006 Elsevier Ltd. All rights reserved.
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页码：627 / 633
页数：7
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