Outcome of gastric antral vascular ectasia and related anemia after orthotopic liver transplantation

被引:0
|
作者
Ali, Saad Emhmed [1 ]
Benrajab, Karim M. [2 ]
Dela Cruz, Anna Christina [2 ]
机构
[1] Univ Kentucky, Coll Med, Dept Internal Med, Div Hosp Med, Lexington, KY 40536 USA
[2] Univ Kentucky, Coll Med, Dept Internal Med, Div Digest Dis & Nutr, 800 Rose St,MN649, Lexington, KY 40536 USA
关键词
Liver cirrhosis; Iron deficiency anemia; End-stage liver disease; Gastroscopy; Gastrointestinal hemorrhage; Liver transplantation; PORTAL HYPERTENSIVE GASTROPATHY; WATERMELON STOMACH; CIRRHOTIC-PATIENTS; DIAGNOSIS;
D O I
10.4254/wjh.v12.i11.1067
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BACKGROUND Gastric antral vascular ectasia (GAVE) is a significant complication of cirrhosis. Numerous medical, surgical, and endoscopic treatment modalities have been proposed with varied satisfactory results. In a few small studies, GAVE and associated anemia have resolved after orthotopic liver transplantation (OLT). AIM To assess the impact of OLT on the resolution of GAVE and related anemia. METHODS We retrospectively reviewed clinical records of adult patients with GAVE who underwent OLT between September 2012 and September 2019. Demographics and other relevant clinical findings were collected, including hemoglobin levels and upper endoscopy findings before and after OLT. The primary outcome was the resolution of GAVE and its related anemia after OLT. RESULTS Sixteen patients were identified. Mean pre-OLT Hgb was 7.7 g/dL and mean 12 mo post-OLT Hgb was 11.9 g/dL, (P = 0.001). Anemia improved (defined as Hgb increased by 2g) in 87.5% of patients within 6 to 12 mo after OLT and resolved completely in half of the patients. Post-OLT esophagogastroduodenoscopy was performed in 10 patients, and GAVE was found to have resolved entirely in 6 of those patients (60%). CONCLUSION Although GAVE and associated anemia completely resolved in the majority of our patients after OLT, GAVE persisted in a few patients after transplant. Further studies in a large group of patients are necessary to understand the causality of disease and to better understand the factors associated with the persistence of GAVE post-transplant.
引用
收藏
页码:1067 / 1075
页数:10
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