FGFR: Proof-of-concept study of AZD4547 in patients with FGFR1 or FGFR2 amplified tumours.

被引:0
|
作者
Smyth, Elizabeth Catherine
Turner, Nicholas C.
Popat, Sanjay
Morgan, Shethah
Owen, Kate
Gillbanks, Angela
Jain, Vikram Kumar
Cunningham, David
机构
[1] Royal Marsden Hosp NHS Fdn Trust, London, England
[2] AstraZeneca, Macclesfield, Cheshire, England
[3] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
TPS2626
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Mechanisms of Efficacy of the FGFR1-3 Inhibitor AZD4547 in Pediatric Solid Tumor Models
    Phanhthilath, Nikki
    Hakim, Sara
    Su, Catherine
    Liu, Andrea
    Subramonian, Divya
    Lesperance, Jacqueline
    Zage, Peter E.
    INVESTIGATIONAL NEW DRUGS, 2020, 38 (06) : 1677 - 1686
  • [42] Incorporation of FGFR1 and FGFR2 amplification status determination in routine molecular prescreening for targeted therapies
    Prudkin, Ludmila
    Aura, Claudia
    Jimenez, Jose
    Peiro, Nerea
    Moreno, Debora
    Martinez, Paola
    Sanchez, Gertrudis
    Del Carmen Diaz, Maria
    Iglesias, Alejandra
    Angeles Diaz, Maria
    Vivancos, Ana
    Rodon, Jordi
    Cortes, Javier
    Oaknin, Ana
    Maria Del Campo, Jose
    Felip, Enriqueta
    Tabernero, Josep
    Nuciforo, Paolo
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [43] Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice
    Smith, Karen Mueller
    Williamson, Theresa L.
    Schwartz, Michael L.
    Vaccarino, Flora M.
    BRAIN RESEARCH, 2012, 1460 : 12 - 24
  • [44] Identification of pathogenic FGFR1, FGFR2, and FGFR3 alterations in cell-free DNA (cfDNA) from patients with metastatic breast cancer
    Taylor, Mary Love
    Mayro, Benjamin
    Drusbosky, Leylah
    Batchelder, Robin
    Marcom, P. Kelly
    Anders, Carey
    Force, Jeremy
    CANCER RESEARCH, 2021, 81 (04)
  • [45] The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT
    Ryan, Molly R.
    Sohl, Christal D.
    Luo, BeiBei
    Anderson, Karen S.
    MOLECULAR CANCER RESEARCH, 2019, 17 (02) : 532 - 543
  • [46] AZD4547 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation: The Role of FGFR1 in Renal Tubular Epithelial Cells
    Chen, Xuemei
    Zhang, Xuejiao
    Xu, Jiajun
    Zhao, Yiqing
    Bao, Jiachun
    Zheng, Zhanxiong
    Han, Jibo
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 14 : 833 - 844
  • [47] Discovery and characterization of selective, FGFR1 sparing, inhibitors of FGFR2/3 oncogenic mutations for the treatment of cancers
    Dardenne, Etienne
    Padilla, Fernando
    Rasmussen, Sara
    Yang, Shao Ning
    Mentes, Ahmet
    Ogawa, Luisa Shin
    Trombino, Anthony
    Romashko, Darlene
    Chevtsova, Maria
    Thakur, Shalabh
    Buck, Elisabeth
    Roberts, Christopher
    Lucas, Matthew
    Lin, Tai-An
    MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
  • [48] Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryo
    Krawczyk, Katarzyna
    Wilczak, Katarzyna
    Szczepanska, Katarzyna
    Maleszewski, Marek
    Suwinska, Aneta
    OPEN BIOLOGY, 2022, 12 (11)
  • [49] Localization patterns of fibroblast growth factor 1 and its receptors FGFR1 and FGFR2 in postnatal mouse retina
    Elisabetta Catalani
    Silvia Tomassini
    Massimo Dal Monte
    Luigi Bosco
    Giovanni Casini
    Cell and Tissue Research, 2009, 336 : 423 - 438
  • [50] Localization patterns of fibroblast growth factor 1 and its receptors FGFR1 and FGFR2 in postnatal mouse retina
    Catalani, Elisabetta
    Tomassini, Silvia
    Dal Monte, Massimo
    Bosco, Luigi
    Casini, Giovanni
    CELL AND TISSUE RESEARCH, 2009, 336 (03) : 423 - 438