Optimum designs for estimating EDp based on raw optical density data

For raw optical density (ROD) data, such as those generated in biological assays employing an ELISA plate reader, EDp-optinial designs are identified for a family of homogeneous non-linear models with two parameters, In every case, the theoretical EDp-optimal design is a design with one or two support points. These theoretical optimal designs might not be suitable for many practical applications. To overcome this shortcoming, we have specified EDp-optimal designs within the class of k-point equally spaced and uniform designs. The efficiency robustness of these designs with respect to initial nominal values of the parameters have been investigated. (C) 2002 Elsevier Science B.V. All rights reserved.