Bioactive Limonoids from the Leaves of Azaridachta indica (Neem)

被引：24

作者：

Gualtieri, Maria J. ^{[1
,2
]}

Malafronte, Nicola ^{[2
]}

Vassallo, Antonio ^{[3
]}

Braca, Alessandra ^{[4
]}

Cotugno, Roberta ^{[2
]}

Vasaturo, Michele ^{[2
]}

De Tommasi, Nunziatina ^{[2
]}

Dal Piaz, Fabrizio ^{[2
]}

机构：

[1] Univ Los Andes, Dept Farmacognosia & Med Organ, Lab Med Organ, Detras HULA,Sect Campo Oro, Merida 5101, Venezuela

[2] Univ Salerno, Dipartimento Farm, I-84084 Fisciano, SA, Italy

[3] Univ Basilicata, Dipartimento Sci, I-85100 Potenza, Italy

[4] Univ Pisa, Dipartimento Farm, I-56126 Pisa, Italy

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 03期

关键词：

AZADIRACHTA-INDICA; TETRACYCLIC TRITERPENOIDS; SIGNAL-TRANSDUCTION; HSP90; INHIBITOR; MELIA-AZEDARACH; TETRANORTRITERPENOIDS; DERIVATIVES; CANCER; 17-AAG; CELLS;

D O I：

10.1021/np400863d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.

引用

页码：596 / 602

页数：7

共 50 条

[21] ANTIFEEDING POTENCY OF NEEM (AZADIRACHTA-INDICA) EXTRACTIVES AND LIMONOIDS AGAINST TERMITE (RETICULITERMES-SPERATUS)
SERIT, M
ISHIDA, M
NAKATA, K
KIM, M
TAKAHASHI, S
JOURNAL OF PESTICIDE SCIENCE, 1992, 17 (04) : 267 - 273
[22] Callus and azadirachtin related limonoids production through in vitro culture of neem (Azadirachta indica A. Juss)
Rafiq, Muhammad
Dahot, Muhammad Umar
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2010, 9 (04): : 449 - 453
[23] Cytotoxicity of nimbolide, epoxyazadiradione and other limonoids from neem insecticide
Cohen, E
Quistad, GB
Casida, JE
LIFE SCIENCES, 1996, 58 (13) : 1075 - 1081
[24] Limonoids from the leaves of Swietenia macrophylla
Liu, Jie-Qing
Wang, Cui-Fang
Chen, Jian-Chao
Qiu, Ming-Hua
NATURAL PRODUCT RESEARCH, 2012, 26 (20) : 1887 - 1891
[25] Gedunin and Azadiradione: Human Pancreatic Alpha-Amylase Inhibiting Limonoids from Neem (Azadirachta indica) as Anti-Diabetic Agents
Ponnusamy, Sudha
Haldar, Saikat
Mulani, Fayaj
Zinjarde, Smita
Thulasiram, Hirekodathakallu
RaviKumar, Ameeta
PLOS ONE, 2015, 10 (10):
[26] Identification and Antifeedant Activities of Limonoids from Azadirachta indica
Yan, Yu-Xin
Liu, Jie-Qing
Wang, Hong-Wei
Chen, Jin-Xiong
Chen, Jian-Chao
Chen, Li
Zhou, Lin
Qiu, Ming-Hua
CHEMISTRY & BIODIVERSITY, 2015, 12 (07) : 1040 - 1046
[27] Microwave-Assisted Improved Extraction and Purification of Anticancer Nimbolide from Azadirachta indica (Neem) Leaves
Suttiarporn, Panawan
Choommongkol, Vachira
MOLECULES, 2020, 25 (12):
[28] Characterization of microRNAs from neem (Azadirachta indica) and their tissue-specific expression study in leaves and stem
Sujay Paul
Paula Reyes-Pérez
Paola Isabel Angulo-Bejarano
Aashish Srivastava
Sathishkumar Ramalingam
Ashutosh Sharma
3 Biotech, 2021, 11
[29] Characterization of microRNAs from neem (Azadirachta indica) and their tissue-specific expression study in leaves and stem
Paul, Sujay
Reyes-Perez, Paula
Isabel Angulo-Bejarano, Paola
Srivastava, Aashish
Ramalingam, Sathishkumar
Sharma, Ashutosh
3 BIOTECH, 2021, 11 (06)
[30] DFT Calculations for Adsorption of Methylene Blue Dye on Neem (Azadirachta indica) Leaves
Singh, Pragya
Kumar, Rajesh
Rachna, Km
Singh, N. B.
Singh, Ram Chandra
Singh, Pramod K.
MACROMOLECULAR SYMPOSIA, 2023, 407 (01)

← 1 2 3 4 5 →