Bioactive Limonoids from the Leaves of Azaridachta indica (Neem)

被引：24

作者：

Gualtieri, Maria J. ^{[1
,2
]}

Malafronte, Nicola ^{[2
]}

Vassallo, Antonio ^{[3
]}

Braca, Alessandra ^{[4
]}

Cotugno, Roberta ^{[2
]}

Vasaturo, Michele ^{[2
]}

De Tommasi, Nunziatina ^{[2
]}

Dal Piaz, Fabrizio ^{[2
]}

机构：

[1] Univ Los Andes, Dept Farmacognosia & Med Organ, Lab Med Organ, Detras HULA,Sect Campo Oro, Merida 5101, Venezuela

[2] Univ Salerno, Dipartimento Farm, I-84084 Fisciano, SA, Italy

[3] Univ Basilicata, Dipartimento Sci, I-85100 Potenza, Italy

[4] Univ Pisa, Dipartimento Farm, I-56126 Pisa, Italy

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 03期

关键词：

AZADIRACHTA-INDICA; TETRACYCLIC TRITERPENOIDS; SIGNAL-TRANSDUCTION; HSP90; INHIBITOR; MELIA-AZEDARACH; TETRANORTRITERPENOIDS; DERIVATIVES; CANCER; 17-AAG; CELLS;

D O I：

10.1021/np400863d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.

引用

页码：596 / 602

页数：7

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