Generation of induced pluripotent stem cell GZHMCi002-A from peripheral blood mononuclear cells with APOB mutation

被引：0
|
作者：
Song Bing [1 ]
Liu Nengqing [1 ]
Cheng Yi [1 ]
Lu Dian [1 ]
Chen Diyu [1 ]
Xie Yingjun [1 ]
He Lina [1 ]
Yang Yinghong [1 ]
Guan Hongmei [1 ]
Sun Xiaofang [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Inst Gynecol & Obstet, Key Lab Major Obstetr Dis Guangdong Prov, Expt Dept,Affiliated Hosp 3, Guangzhou 510150, Guangdong, Peoples R China
[2] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510005, Peoples R China
来源：
STEM CELL RESEARCH | 2020年 / 49卷
基金：
中国国家自然科学基金;
关键词：
INDUCTION;
D O I：
10.1016/j.scr.2020.102054
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Apolipoprotein (apo) B is a large, amphipathic glycoprotein which plays an important role in human lipoprotein metabolism. The 43-kb APOB gene located on the short arm of human chromosome 2 and consisted of 29 exons, mutations in the APOB gene can give rise to either hypo- or hypercholesterolemia. We used peripheral blood mononuclear cells (PBMCs) from a volunteer carrying the APOB mutation (c.10579C > T, p.Arg3527Trp) located in exon 9 to establish induced pluripotent stem cells (iPSC), which will be an effective means to reveal the key biologically relevant metabolic mechanisms, a powerful tool for medicine selection and related research.
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页数：4
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