α-Glucosidase and lipoxygenase inhibitory derivatives of cryptosporioptide from the endophytic fungus Cryptosporiopsis sp.

被引：6

作者：

Tousif, Muhammad Imran ^{[1
]}

Shazmeen, Natasha ^{[1
]}

Riaz, Naheed ^{[1
]}

Shafiq, Nusrat ^{[1
]}

Khatoon, Tasneem ^{[2
]}

Schulz, Barbara ^{[3
]}

Ashraf, Muhammad ^{[4
]}

Shaukat, Ayesha ^{[4
]}

Hussain, Hidayat ^{[5
]}

Jabbar, Abdul ^{[1
]}

Saleem, Muhammad ^{[1
]}

机构：

[1] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur 63100, Pakistan

[2] Univ Bahawalpur, Govt Sadiq Women Coll, Bahawalpur 63100, Pakistan

[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Microbiol, D-31806 Braunschweig, Germany

[4] Islamia Univ Bahawalpur, Dept Biochem & Biotechnol, Bahawalpur 63100, Pakistan

[5] Univ Nizwa, Coll Arts & Sci, Dept Biol Sci & Chem, Birkat Al Mouz 616, Nizwa, Oman

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 11期

关键词：

isolation; Cryptosporiopsis fungus; structure elucidation; enzyme inhibition; cryptosporioptide derivatives; STROBILURUS-OHSHIMAE; SESQUITERPENOIDS;

D O I：

10.1080/10286020.2014.938647

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new cryptosporioptide-derived polyketides cryptosporioptides A (2) and B (3) were isolated from the extract of endophytic fungus Cryptosporiopsis sp. associated with the shrub, Viburnum tinus. The structures of the isolates were determined through spectral analysis including 1D NMR (H-1, C-13) and 2D NMR (HSQC, HMBC, COSY) techniques, HR-FAB-MS and by comparison with the reported data of cryptosporioptide (1). The relative stereochemistry was assigned with the help of NOESY analysis, the molecular model, and comparison of the optical rotation values with the reference compound 1.

引用

页码：1068 / 1073

页数：6

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