Posttransplant lymphoproliferative disorder presenting as CD30+, ALK+, anaplastic large cell lymphoma in a child

被引：5
|
作者：
Sebire, NJ [1 ]
Malone, M [1 ]
Ramsay, AD [1 ]
机构：
[1] Great Ormond St Hosp Sick Children, Dept Histopathol, London WC1E 3JH, England
来源：
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | 2004年 / 7卷 / 03期
关键词：
ALK; anaplastic large cell lymphoma; CD30; posttransplant lymphoproliferative disorder;
D O I：
10.1007/s10024-003-9094-8
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
We report a 15-year-old cardiac transplant recipient who developed a monomorphic posttransplant lymphoproliferative disorder (PTLPD) which demonstrated morphological and immunohistochemical features of anaplastic large cell lymphoma including CD30 and anaplastic lymphoma kinase (ALK) immunopositivity but lacking the commonly associated t(2;5) translocation. The neoplastic cells were Epstein-Barr Virus (EBV)-negative. T-cell PTLPD is an uncommon but recognized late complication in solid organ transplant recipients. This is the first reported case, to our knowledge, of PTLPD occurring in childhood with an ALK+, CD30+ anaplastic large cell lymphoma phenotype.
引用
收藏
页码：290 / 293
页数：4
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