Pressing Mitochondrial Genetics Forward

被引：3
|
作者：
Chen, Yu-Chan [1 ]
Rutter, Jared [1 ]
机构：
[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84112 USA
来源：
CELL REPORTS | 2014年 / 7卷 / 03期
关键词：
ADENYLATE KINASE;
D O I：
10.1016/j.celrep.2014.04.028
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mitochondria are crucial for many cellular functions. In this issue of Cell Reports, studies from Lanning et al. and Wolf and Mootha describe RNAi approaches to screening the mitochondrial proteome. Unexpectedly, they uncover key roles for two poorly characterized mitochondrial proteins: AK4 and FASTKD4. These studies provide examples of the power of forward genetic screens, even when screening a subset of genes, in deciphering functions of previously mysterious mitochondrial proteins.
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页码：599 / 600
页数：2
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