E-cadherin promoter polymorphisms are not associated with the aggressiveness of prostate cancer in Caucasian patients

被引:3
|
作者
Li, He-Cheng
Albert, Jeffrey M.
Shinohara, Eric T.
Cai, Qiuyin
Freyer, Andrea
Cai, Hui
Cao, Carolyn
Wang, Zuofei
Kataoka, Nobuhiko
Teng, Ming
Zheng, Wei
Lu, Bo [1 ]
机构
[1] Vanderbilt Univ, Sch Med, Dept Radiat Oncol, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA
关键词
prostate cancer; E-cadherin; promoter; polymorphism; aggressiveness;
D O I
10.1016/j.urolonc.2006.02.018
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: -160C -> A and -347G -> GA polymorphisms in the promoter region decrease E-cadherin gene transcription. Decreased E-cadherin expression predicts poor outcome among patients with cancer. We sought to investigate whether -160C -> A and/or -347G -> GA polymorphisms were associated with the aggressiveness of prostate cancer. Methods: TaqMan single nucleotide polymorphism genotyping assay (Applied Biosystems, Foster City, CA) was used to detect -160C -> A and -347G -> GA polymorphisms in deoxyribonucleic acid from the paraffin-embedded prostate tissues of 98 Caucasian patients. Results: The genotype frequencies were -160C/C: 48% (47 of 98); -160C/A: 44% (43 of 98); -160A/A: 8% (8 of 98); -347G/G: 68% (67 of 98); -347G/GA: 28% (27 of 98); and -347GA/GA: 4% (4 of 98). Using the chi-square test, we found that the polymorphisms -160C -> A and -347G -> GA were not related to other clinical and pathologic parameters (i.e., age, prostate-specific antigen level, Gleason grade, and clinical stage) (P > 0.05). In combination analysis, there was no significant relationship between patients with both -160C/C and -347G/G, and these same parameters (P > 0.05). Using the log-rank test, we found no significant difference in relapse-free survival and overall survival between patients with -160C/C and those with -160A/C or -160A/A (P = 0.0764 and 0.2746, respectively), and also no significant difference between patients with -347G/G and those with -347GA/G or -347GA/GA (P = 0.9416 and 0.7367, respectively). There was also no significant difference in relapse-free survival and overall survival between patients with homozygosities of -160C/-347G and patients with other genotypes (P = 0.1418 and 0.2434, respectively). Conclusion: We conclude that E-cadherin -160C -> A and/or -347G -> GA polymorphisms are not associated with the aggressiveness of prostate cancer in Caucasian patients. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:496 / 502
页数:7
相关论文
共 50 条
  • [31] E-cadherin plasticity in prostate cancer stem cell invasion
    Bae, Kyung-Mi
    Parker, Nicole N.
    Dai, Yao
    Vieweg, Johannes
    Siemann, Dietmar W.
    AMERICAN JOURNAL OF CANCER RESEARCH, 2011, 1 (01): : 71 - 84
  • [32] Friend or foe: role of E-cadherin in prostate cancer metastasis
    Lin, Ching-Yu
    Chuu, Chih-Pin
    TRANSLATIONAL ANDROLOGY AND UROLOGY, 2016, 5 (06) : 961 - +
  • [33] Characterization of DNA polymorphisms in the E-cadherin gene (CDH1) promoter region
    Nakamura, A
    Shimazaki, T
    Kaneko, K
    Shibata, M
    Matsumura, T
    Nagai, M
    Makino, R
    Mitamura, K
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2002, 502 (1-2) : 19 - 24
  • [34] Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations
    Zhang, Baozhen
    Pan, Kaifeng
    Liu, Zhaojun
    Zhou, Jing
    Gu, Liankun
    Ji, Jiafu
    Ma, Junling
    You, Wei-cheng
    Deng, Dajun
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (09) : 2402 - 2408
  • [35] Altered expression of β-catenin, E-cadherin, and E-cadherin promoter methylation in epithelial ovarian carcinoma
    Bhagat, Rahul
    Premalata, C. S.
    Shilpa, V.
    Pallavi, V. R.
    Ramesh, G.
    Vijay, C. R.
    Krishnamoorthy, Lakshmi
    TUMOR BIOLOGY, 2013, 34 (04) : 2459 - 2468
  • [37] CDH1 POLYMORPHISMS AND LOW EXPRESSION OF E-CADHERIN AND β-CATENIN IN COLORECTAL CANCER PATIENTS
    Martinelli, M.
    Palmieri, A.
    Rodia, M. T.
    Cura, F.
    Scapoli, L.
    Ugolini, G.
    Montroni, I.
    de Sanctis, P.
    Solmi, R.
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2015, 29 (03): : 89 - 96
  • [38] E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids
    Ierodiakonou, D.
    Postma, D. S.
    Koppelman, G. H.
    Boezen, H. M.
    Gerritsen, J.
    ten Hacken, N.
    Timens, W.
    Vonk, J. M.
    EUROPEAN RESPIRATORY JOURNAL, 2011, 38 (05) : 1044 - 1052
  • [39] -160C/A polymorphism in the E-cadherin gene promoter and risk of hereditary, familial and sporadic prostate cancer
    Jonsson, BA
    Adami, HO
    Hägglund, M
    Bergh, A
    Göransson, I
    Stattin, P
    Wiklund, F
    Grönberg, H
    INTERNATIONAL JOURNAL OF CANCER, 2004, 109 (03) : 348 - 352
  • [40] Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer
    Chan, AOO
    Lam, SK
    Wong, BCY
    Wong, WM
    Yuen, MF
    Yeung, YH
    Hui, WM
    Rashid, A
    Kwong, YL
    GUT, 2003, 52 (04) : 502 - 506