Betulinic acid and its derivatives as anti-angiogenic agents

被引：67
|
作者：
Mukherjee, R
Jaggi, M
Rajendran, P
Siddiqui, MJA
Srivastava, SK
Vardhan, A
Burman, AC
机构：
[1] Dabur Res Fdn, Div Expt Oncol, Ghaziabad 201010, Uttar Pradesh, India
[2] Dabur Res Fdn, Chem Res, Ghaziabad 201010, Uttar Pradesh, India
[3] Dabur Res Fdn, Med Chem, Ghaziabad 201010, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 09期
关键词：
D O I：
10.1016/j.bmcl.2004.02.044
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Betulinic acid (1) significantly caused cytotoxicity to endothelial cell line ECV304 (IC50 1.26 +/- 0.44 mug/mL) in a 5-day MTT assay. Novel and more potent derivatives of betulinic acid (2, 4, 6-8) have been synthesized with IC50 less than 0.4 mug/mL. The endothelial cell specificity against human tumor cell lines DU145, L132, A549, and PA-1 were determined. Further betulinic acid (1) inhibited TLS formation of ECV304 cells on Matrigel(TM) by 5.5% while its derivatives caused an inhibition of 13.1-49.2%. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2181 / 2184
页数：4
相关论文
共 50 条
  • [41] Overview of anti-angiogenic agents in development for ovarian cancer
    Burger, Robert A.
    GYNECOLOGIC ONCOLOGY, 2011, 121 (01) : 230 - 238
  • [42] Combining Immune Checkpoint Inhibitors with Anti-Angiogenic Agents
    Ciciola, Paola
    Cascetta, Priscilla
    Bianco, Cataldo
    Formisano, Luigi
    Bianco, Roberto
    JOURNAL OF CLINICAL MEDICINE, 2020, 9 (03)
  • [43] Predicting benefit from anti-angiogenic agents in malignancy
    Adrian M. Jubb
    Adam J. Oates
    Scott Holden
    Hartmut Koeppen
    Nature Reviews Cancer, 2006, 6 : 626 - 635
  • [44] METABOLIC IMPACT OF ANTI-ANGIOGENIC AGENTS ON GLIOMA CELLS
    Mesti, T.
    Savarin, P.
    Triba, M. N.
    Ocvirk, J.
    Banissi, C.
    Carpentier, A. F.
    NEURO-ONCOLOGY, 2014, 16
  • [45] Checkpoint inhibitors and anti-angiogenic agents: a winning combination
    Brest, Patrick
    Mograbi, Baharia
    Pages, Gilles
    Hofman, Paul
    Milano, Gerard
    BRITISH JOURNAL OF CANCER, 2023, 129 (09) : 1367 - 1372
  • [46] Targeting the vasculature: anti-angiogenic agents for malignant mesothelioma
    Chia, Puey Ling
    Russell, Prudence A.
    Scott, Andrew M.
    John, Thomas
    EXPERT REVIEW OF ANTICANCER THERAPY, 2016, 16 (12) : 1235 - 1245
  • [47] Predicting benefit from anti-angiogenic agents in malignancy
    Jubb, Adrian M.
    Oates, Adam J.
    Holden, Scott
    Koeppen, Hartmut
    NATURE REVIEWS CANCER, 2006, 6 (08) : 626 - 635
  • [48] Development of thalidomide analogs as anti-angiogenic agents.
    Shi, JD
    Xiao, ZL
    Marks, M
    Kamat, C
    Pokala, V
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U653 - U653
  • [49] Checkpoint inhibitors and anti-angiogenic agents: a winning combination
    Patrick Brest
    Baharia Mograbi
    Gilles Pagès
    Paul Hofman
    Gerard Milano
    British Journal of Cancer, 2023, 129 : 1367 - 1372
  • [50] Recent progress on betulinic acid and its derivatives as antitumor agents: a mini review
    ZHONG Ye
    LIANG Nan
    LIU Yang
    CHENG Mao-Sheng
    ChineseJournalofNaturalMedicines, 2021, 19 (09) : 641 - 647
12345