Palladium-catalysed asymmetric allylic substitution: Synthesis of alpha- and beta-amino acids

Methodology has been established for the formation of enantiomerically enriched alpha-amino acids using palladium-catalysed allylic amination, The formation of enantiomerically enriched allylamines has been achieved with high enantioselectivity, Oxidative cleavage of the allylamines provides arylglycine and glutamic acid derivatives, Additionally, enantiomerically enriched beta-amino acids have been prepared in high enantiomeric excess, Palladium-catalysed asymmetric allylic substitution is used as the key synthetic transformation.