5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer

被引:8
|
作者
Suppli, N. P. [1 ,2 ]
Bukh, J. D. [2 ]
Moffitt, T. E. [3 ,4 ,5 ]
Caspi, A. [3 ,4 ,5 ]
Johansen, C. [1 ,6 ]
Albieri, V. [7 ]
Tjonneland, A. [8 ]
Kessing, L. V. [2 ]
Dalton, S. O. [1 ]
机构
[1] Danish Canc Soc, Res Ctr, Unit Survivorship, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Psychiat Ctr Copenhagen, Copenhagen, Denmark
[3] Duke Univ, Ctr Genom & Computat Biol, Dept Psychol & Neurosci, Durham, NC USA
[4] Duke Univ, Ctr Genom & Computat Biol, Dept Psychiat & Behav Sci, Durham, NC USA
[5] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London, England
[6] Rigshosp, Dept Oncol, Finsenctr, DK-2100 Copenhagen, Denmark
[7] Danish Canc Soc, Res Ctr, Unit Stat Bioinformat & Registry, DK-2100 Copenhagen, Denmark
[8] Danish Canc Soc, Res Ctr, Unit Diet Genes & Environm, DK-2100 Copenhagen, Denmark
来源
TRANSLATIONAL PSYCHIATRY | 2015年 / 5卷
关键词
MENTAL-HEALTH; STRESS; POLYMORPHISM; DIAGNOSIS; RISK; LIFE; DISORDERS; DISTRESS; QUALITY; MODEL;
D O I
10.1038/tp.2015.121
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The serotonin-transporter-linked polymorphic region (5-HTTLPR) is one of the most extensively investigated candidates to be involved in gene-environment interaction associated with depression. Nevertheless, the interaction remains controversial. In an original study, we tested the hypothesis that risk for use of antidepressants following a diagnosis of colorectal cancer is associated with bi-and triallelic genotypes of 5-HTTLPR. In addition, in an inclusive meta-analysis, we tested the hypothesis that depression following a diagnosis of cancer is associated with biallelic 5-HTTLPR genotype. We created an exposed-only cohort of 849 colorectal cancer patients from the Danish Diet, Cancer and Health cohort study. The hypothesized association was investigated with Cox regression models and competing risk analyses. Five studies comprising a total of 1484 cancer patients were included in the metaanalysis. Nationwide registries provided information on dates of diagnosis of colorectal cancer and use of antidepressants. Unadjusted odds ratios of depression according to the biallelic 5-HTTLPR genotype were included in the meta-analysis. 5-HTTLPR genotypes were not associated with use of antidepressants after colorectal cancer. Estimated hazard ratios ranged 0.92-1.08, and we observed no statistically significant associations across biallelic and triallelic genotypes in crude as well as adjusted models. The meta-analysis showed no statistically significant associations of 5-HTTLPR biallelic genotype with depression after cancer. Our findings in an original study and a meta-analysis do not support the hypothesis of an association between the 5-HTTLPR genotype and depression after cancer.
引用
收藏
页码:e631 / e631
页数:6
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