A [17F]-fluoromethane PET/TMS study of effective connectivity

被引：40
|
作者：
Ferrarelli, F
Haraldsson, HM
Barnhart, TE
Roberts, AD
Oakes, TR
Massimini, M
Stone, CK
Kalin, NH
Tononi, G
机构：
[1] Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA
[2] Univ Wisconsin, WM Keck Lab Funct Brain Imaging, Madison, WI 53719 USA
[3] Univ Wisconsin, Dept Med Phys, Madison, WI 53719 USA
[4] Univ Manchester, Christie Hosp, Mol Imaging Ctr, Manchester M13 9PL, Lancs, England
来源：
BRAIN RESEARCH BULLETIN | 2004年 / 64卷 / 02期
关键词：
transcranial magnetic stimulation; positron emission tomography; effective connectivity; fluoromethane; functional neuroimaging;
D O I：
10.1016/j.brainresbull.2004.04.020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [F-17]-[CH3F] ([F-17]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [O-15]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：103 / 113
页数：11
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