Iron-mediated remote C-H bond benzylation of 8-aminoquinoline amides

被引：20
|
作者：
Cui, Mian [1 ]
Liu, Jing-Hui [1 ]
Lu, Xiao-Yu [1 ]
Lu, Xi [1 ]
Zhang, Zhen-Qi [1 ]
Xiao, Bin [1 ]
Fu, Yao [1 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 20期
关键词：
Two component reaction; C-H functionalization; Iron-catalyzed; Benzylation; Quinoline; FRIEDEL-CRAFTS REACTIONS; DIRECT ARYLATION; CARBON-NITROGEN; UNACTIVATED C(SP(3))-H; CATALYZED CLEAVAGE; COPPER; QUINOLINES; SULFONAMIDES; FUNCTIONALIZATION; ALKYLATION;
D O I：
10.1016/j.tetlet.2017.02.090
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and convenient method for C5-benzylation of quinoline frameworks is developed with the using of inexpensive FeCl3 catalyst. A range of N-bisbenzylic and N-monobenzylic sulfonamides smoothly react with aliphatic amides and aromatic amides, giving the corresponding products in moderate to excellent yields. (C) 2017 Published by Elsevier Ltd.
引用
收藏
页码：1912 / 1916
页数：5
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