Nanoparticle-based detection of cancer-associated RNA

被引：1
|
作者：
Elbehery, Ali H. A. [1 ]
Azzazy, Hassan M. E. [2 ,3 ]
机构：
[1] Amer Univ Cairo, Sch Sci & Engn, Grad Program Biotechnol, New Cairo, Egypt
[2] Amer Univ Cairo, Yousef Jameel Sci & Technol Res Ctr, New Cairo, Egypt
[3] Amer Univ Cairo, Sch Sci & Engn, Dept Chem, New Cairo, Egypt
来源：
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2014年 / 6卷 / 04期
关键词：
MESSENGER-RNA; CIRCULATING MICRORNAS; EXPRESSION ANALYSIS; ALTERED EXPRESSION; GOLD-NANOBEACONS; GENE-EXPRESSION; NONCODING RNAS; NANO-FLARES; QUANTIFICATION; RECOGNITION;
D O I：
10.1002/wnan.1266
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
According to the World Health Organization (WHO), cancer cases are expected to increase globally by 57% over the coming two decades. A critical factor in the management of cancer is early detection using highly sensitive diagnostic techniques. RNAs play a vital role in cancer pathogenesis. The detection of aberrant and/or abnormally expressed RNA has been reported in several cancers. Nanoparticle-based assays have been shown to have enhanced specificity and sensitivity as compared with conventional methods. In addition, nanoparticles have enabled the development of new diagnostic strategies. This review covers nanoparticle-based techniques used for the detection of mRNA and micro-RNA associated to different cancers. (C) 2014 Wiley Periodicals, Inc.
引用
收藏
页码：384 / 397
页数：14
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