Nickel-Catalyzed C-H Alkylations: Direct Secondary Alkylations and Trifluoroethylations of Arenes

被引：239
|
作者：
Song, Weifeng [1 ]
Lackner, Sebastian [1 ]
Ackermann, Lutz [1 ]
机构：
[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 09期
基金：
欧洲研究理事会;
关键词：
auxiliary assistance; C-H activation; nickel; secondary alkylation; trifluoroethylation; UNACTIVATED C(SP(3))-H BONDS; ELECTRON-DEFICIENT ARENES; CROSS-COUPLING REACTIONS; ALKYL-HALIDES; AROMATIC AMIDES; ACID DERIVATIVES; ACTIVATION; FUNCTIONALIZATION; ARYLATION; HYDROHETEROARYLATION;
D O I：
10.1002/anie.201309584
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A versatile nickel catalyst allowed for C-H alkylations of unactivated arenes with challenging secondary alkyl bromides and chlorides. The high catalytic efficacy also set the stage for direct secondary alkylations of indoles as well as C-H trifluoroethylations with ample substrate scope.
引用
收藏
页码：2477 / 2480
页数：4
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