Regulation of aquaporin-2 water channel trafficking by vasopressin

被引：132
|
作者：
Knepper, MA
Inoue, T
机构：
[1] Lab. Kidney and Electrolyte Metab., Natl. Heart, Lung and Blood Inst., National Institutes of Health, Bethesda, MD 20892-0951
来源：
CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 04期
关键词：
D O I：
10.1016/S0955-0674(97)80034-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct. The aquaporin-2 water channel has been demonstrated to be the target for this action of vasopressin. Recent studies have demonstrated that vasopressin, acting through cyclic AMP, triggers fusion of aquaporin-2-bearing vesicles with the apical plasma membrane of the collecting duct principal cells. The vesicle-targeting proteins synaptobrevin-2 and syntaxin-4 are proposed to play roles in this process.
引用
收藏
页码：560 / 564
页数：5
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